Decreased motor cortex γ-aminobutyric acid in amyotrophic lateral sclerosis
Foerster BR et al. – Decreased levels of γ–aminobutyric acid (GABA) are present in the motor cortex of patients with amyotrophic lateral sclerosis (ALS) compared to healthy controls (HCs). Findings are consistent with prior reports of alterations in GABA receptors in the motor cortex as well as increased cortical excitability in the context of ALS. Larger, longitudinal studies are needed to confirm these findings and to further the understanding of the role of GABA in the pathogenesis of ALS.