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Confirmation of the efficacy of vitamin B6 supplementation for McArdle disease by follow-up muscle biopsy
Muscle & Nerve, 09/02/2011
Clinical Article
Sato S et al. – No effective treatment for McArdle disease exists. The authors report on a Japanese patient with McArdle disease who was treated with vitamin B6 supplementation (60–90 mg/day). After treatment, increased muscle phosphorylase activity was confirmed by follow–up muscle biopsy (3.8 times higher than pre–treatment levels). Increased lactate levels were seen on the forearm exercise test, and regular work activities could be resumed. Vitamin B6 supplementation can enhance residual phosphorylase activity and improve insufficient anaerobic glycolysis of skeletal muscle.