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Dynamic cerebral autoregulation after intracerebral hemorrhage: A case-control study Full Text
BMC Neurology, 09/01/2011
Nakagawa K et al. – Patients with intracerebral hemorrhage(ICH) had higher gains in a wide range of frequency ranges compared to controls. These findings suggest that dynamic cerebral autoregulation may be less effective in the early days after ICH.
Methods- 21 patients (66+/-15 years) with early (<72 hours) lobar or basal ganglia ICH were prospectively studied and compared to twenty-three age-matched controls (65+/-9 years).
- Continuous measures of mean flow velocity (MFV) in the middle cerebral artery and mean arterial blood pressure (MAP) were obtained over 5 min.
- Cerebrovascular resistance index (CVRi) was calculated as the ratio of MAP to MFV.
- Dynamic cerebral autoregulation was assessed using transfer function analysis of spontaneous MAP and MFV oscillations in the low (0.03-0.15 Hz) and high (0.15-0.5 Hz) frequency ranges.
- ICH group demonstrated higher CVRi compared to controls (ipsilateral: 1.91+/-1.01 mmHg*s*cm-1, p=0.04; contralateral: 2.01+/-1.24 mmHg*s*cm-1, p=0.04; vs. control: 1.42+/-0.45 mmHg*s*cm-1).
- ICH group had higher gains than controls in the low (ipsilateral: 1.33+/-0.58 %/mmHg, p=0.0005; contralateral: 1.47+/-0.98 %/mmHg, p=0.004; vs. control: 0.82+/-0.30 %/mmHg) and high (ipsilateral: 2.11+/-1.31 %/mmHg, p<0.0001; contralateral: 2.14+/-1.49 %/mmHg, p<0.0001; vs. control: 0.66+/-0.26 %/mmHg) frequency ranges.
- ICH group also had higher coherence in the contralateral hemisphere than the control (ICH contralateral: 0.53+/-0.38, p=0.02; vs. control: 0.38+/-0.15) in the high frequency range.
