Showing Latest Articles
The Use of S100B and Tau Protein Concentrations in the Cerebrospinal Fluid for the Differential Diagnosis of Bacterial Meningitis: A Retrospective Analysis
European Neurology, 08/29/2011
Clinical Article
Jung K et al. – In contrast to TauCSF, S100BCSF concentrations ≥3.1 ng/ml are promising to discriminate bacterial from viral meningitis.
Methods- S100BCSF, TauCSF, and routine parameters (CSF leukocyte count, proteinCSF, lactateCSF, serum C–reactive protein, blood leukocyte count and body temperature) were analyzed in 33 patients with microbiologically confirmed bacterial meningitis (BM) and in 19 with benign viral(VM).
- Their classification accuracy, sensitivity and specificity were studied by receiver operating characteristic (ROC) curves.
- S100BCSFconcentrations were higher in BM than in VM patients (p=0.03) and showed a promising accuracy (90%) for the differential diagnosis of BM versus VM.
- Its discriminative properties were comparable to routine parameters.
- Of all parameters, S100BCSF showed the highest specificity (100%) with an optimal cut–off of 3.1 ng/ml. TauCSF concentrations were useless for the discrimination (p=0.64).