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Spinal Cord Stimulation and Cerebral Hemodynamics: Updated Mechanism and Therapeutic Implications
Stereotactic and Functional Neurosurgery , 08/19/2011
Visocchi M et al. – The authors revised the published experiences in humans with hypoperfusion syndromes and ‘adjuvant’ locoregional cerebral blood flow(CBF) increase in chemotherapy of brain tumors. Spinal Cord Stimulation(SCS) represents a new perspective in challenging neurosurgical clinical fields such as cerebral ischemia and vasospasm, and seems promising as a new trend of functional neurosurgery in cerebrovascular diseases.
- This paper reviews the main laboratory observations and analyzes the most significant neurophysiological theories on the SCS-mediated effect on CBF.
- Most significant experimental data have been discussed, with specific reference to possible mechanisms such as ‘functional reversible sympathectomy’, cerebral infarction and related ischemic edema, hemodynamic deterioration in experimental combined ischemic-traumatic brain injury and cerebral vasospasm.
- This paper reviews the main laboratory observations and analyzes the most significant neurophysiological theories on the SCS-mediated effect on CBF.