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Gabapentin: An update of its pharmacological properties and therapeutic use in epilepsy
Journal of Research in Medical Sciences, 08/18/2011
Clinical Article
Honarmand A et al. - Gabapentin (GBP) has a well recognized clinical efficacy in those types of focal epilepsy which were resistant to the traditional AEDs.
- The new antiepileptic medications are prescribed for the treatment of patients with seizure disorders since 17 years ago.
- Gabapentin (GBP) was approved on January 1994 as adjunctive treatment in patients 12 years or older with partial seizures, with or devoid of secondary generalization.
- GBP, was formerly known as an anticonvulsant γ-aminobutyric acid (GABA) mimetic, is considered as a safe and well-tolerated antiepileptic drug (AED) with promising pharmacokinetic properties and a wide therapeutic index.
- GBP is useful for the therapy of mixed seizure disorders and refractory partial seizures in children.
- GBP must be regarded as the first treatment for older patients with recently diagnosed seizures.