Marineo G et al. – In this pilot randomized trial, Scrambler therapy appeared to relieve chronic neuropathic pain better than guideline–based drug management.Methods
- A clinical trial with patients randomized to either guideline–based pharmacological treatment or Scrambler therapy for a cycle of 10 daily sessions was performed.
- Patients were matched by type of pain including postsurgical neuropathic pain, postherpetic neuralgia, or spinal canal stenosis.
- Primary outcome was change in visual analog scale (VAS) pain scores at one month; secondary outcomes included VAS pain scores at two and three months, pain medication use, and allodynia.
- Fifty–two patients were randomized.
- The mean VAS pain score before treatment was 8.1 points (control) and 8.0 points (Scrambler).
- At one month, the mean VAS score was reduced from 8.1 to 5.8 (–28%) in the control group, and from 8 to 0.7 points (–91%) in the Scrambler group (P<0.0001).
- At two and three months, the mean pain scores in the control group were 5.7 and 5.9 points, respectively, and 1.4 and 2 points in the Scrambler group, respectively (P<0.0001).
- More relapses were seen in polyradicular pain than monoradicular pain, but retreatment and maintenance therapy gave relief.
- No adverse effects were observed.