Efficacy and acceptability of selective serotonin reuptake inhibitors for the treatment of depression in Parkinsons disease: a systematic review and meta-analysis of randomized controlled trials Full Text
BMC Neurology, 06/24/2010
Evidence Based Medicine
Skapinakis P et al. – Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressants for the treatment of depression in patients with Parkinson's Disease (PD) but data on their efficacy are controversial...These results suggest that there is insufficient evidence to reject the null hypothesis of no differences in efficacy between SSRIs and placebo in the treatment of depression in PD. Due to the limited number of studies and the small sample sizes a type II error (false negative) cannot be excluded. The comparison between SSRIs and TCAs is based on only three studies and further trials with more pragmatic design are needed.