Silencing Nogo-A promotes functional recovery in demyelinating disease
Annals of Neurology , 05/13/2010
Yang Y et al. – Silencing Nogo–A in EAE promotes functional recovery. The therapeutic benefit appears to be mediated by axonal growth and repair, and is not attributable to changes in the encephalitogenic capacity of the myelin–specific T cells. Silencing Nogo–A may be a therapeutic option for MS patients to prevent permanent functional deficits caused by immune–mediated axonal damage.