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Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression
The Journal of Clinical Investigation, 07/11/2012
Kim H et al. – These results reveal an indoleamine 2,3–dioxygenase 1 (IDO1)–mediated regulatory mechanism underlying the comorbidity of pain and depression and suggest a new strategy for the concurrent treatment of both conditions via modulation of brain IDO1 activity.
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