Short latency afferent inhibition in Parkinsons disease patients with dementia
Movement Disorders, 06/08/2012

Celeb O et al. – The findings add further evidence that differential cholinergic deficiency occurs in Parkinson's disease (PD) and PD dementia (PDD). Short-latency afferent inhibition (SAI)can be a neurophysiological correlate of PDD.

• SAI and neuropsychological profile were studied in nondemented PD, PDD, Alzheimer's disease (AD) patients, and age-matched controls.

• SAI was significantly impaired in AD cases (94.7 ± 6.2 versus 55.5 ± 4.0; P<0.0001).
• In PD patients, it was not different from controls (61.4 ± 5.8 versus 55.5 ± 4.0; P=0.412).
• PDD cases demonstrated a significant impairment in SAI (91.4 ± 5.2 versus 55.5 ± 4.0; P<0.0001).
• A high correlation was found between SAI and Mini–Mental State Examination (r=-0.68; P<0.0001).