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Neurology - Demyelinating Disorders News & Articles
What’s your first-line option for current Neurology information? MDLinx Neurology! Where else but MDLinx Neurology will you find subspecialty coverage of articles published on dementia, headache, movement disorders, neurologic oncology, neurosensory disorders, neurosurgery, pain medicine, pediatric neurology, sleep, spine and more? Also discover the latest clinical pearls from the Smartest Neurologist daily quiz competition and Neurology Physician Review. In less than five minutes a day, you can skim the summaries of pertinent articles within 24 hours of publication. Do you need the 2-minute update? Skip to the highlights from our physician editor, D. Scott Cunningham, MD, PhD, for the “can’t miss” summaries on hot topics in neurology and related subspecialties.
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Articles
Latest (2) Full Text Articles (94) Focus on Seizures and Epilepsy441 Truncating mutations in FUS/TLS give rise to a more aggressive ALS-phenotype than missense mutations: a clinico-genetic study in Germany European Journal of Neurology, December 10, 2012
442 Intakes of vitamin C and carotenoids and risk of amyotrophic lateral sclerosis: Pooled results from 5 cohort studies Annals of Neurology , December 7, 2012 Clinical Article
443 Clinical assessment and management of sleep disorders in multiple sclerosis: a literature review Acta Neurologica Scandinavica, December 7, 2012
444 A Psychometric Validation of Two Brief Measures to Assess Palliative Need in Patients Severely Affected by Multiple Sclerosis Journal of Pain and Symptom Management, December 6, 2012 Clinical Article
445 Long-term outcome of paediatric-onset multiple sclerosis: a population-based study Journal of Neurology, Neurosurgery & Psychiatry, December 5, 2012 Clinical Article
446 Validity of an Observation Method for Assessing Pain Behavior in Individuals With Multiple Sclerosis Journal of Pain and Symptom Management, December 4, 2012 Clinical Article
447 Prospective Examination of Anxiety and Depression Before and During Confirmed and Pseudoexacerbations in Patients With Multiple Sclerosis Psychosomatic Medicine, December 3, 2012 Clinical Article
448 The Association of Depression with Pain-Related Treatment Utilization in Patients with Multiple Sclerosis Pain Medicine, December 3, 2012 Clinical Article
449 Heat sensitive persons with multiple sclerosis are more tolerant to resistance exercise than to endurance exercise Multiple Sclerosis Journal, December 3, 2012 Clinical Article
450 Vitamin D as a protective factor in multiple sclerosis Neurology, November 30, 2012 Clinical Article
451 Treatment with interferon-beta does not induce anti-nuclear and anti-neuronal serum autoantibodies in multiple sclerosis patients Journal of Neuroimmunology, November 30, 2012
452 Systemic treatment with the inhibitory neurotransmitter gamma-aminobutyric acid aggravates experimental autoimmune encephalomyelitis by affecting proinflammatory immune responses Journal of Neuroimmunology, November 30, 2012
453 Novel mutation in VCP gene causes atypical amyotrophic lateral sclerosis Neurology, November 30, 2012
454 Multiple sclerosis risk genotypes correlate with an elevated cerebrospinal fluid level of the suggested prognostic marker CXCL13 Multiple Sclerosis Journal, November 29, 2012 Clinical Article
455 How do C9ORF72 repeat expansions cause amyotrophic lateral sclerosis and frontotemporal dementia Current Opinion in Neurology, November 29, 2012
456 Ubiquilin 2 mutations in Italian patients with amyotrophic lateral sclerosis and frontotemporal dementia Journal of Neurology, Neurosurgery & Psychiatry, November 29, 2012
457 Evaluation of Th17-related cytokines and receptors in multiple sclerosis patients under interferon beta-1 therapy Journal of Neuroimmunology, November 29, 2012
458 Association of HLA-DRB1 1501 tagging rs3135388 gene polymorphism with multiple sclerosis Journal of Neuroimmunology, November 29, 2012
459 Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: a randomised controlled phase 3 trial The Lancet, November 28, 2012 Clinical Article
460 Cost Effectiveness of Oromucosal Cannabis-Based Medicine (Sativex) for Spasticity in Multiple Sclerosis PharmacoEconomics, November 28, 2012 Clinical Article
Clinical Pearls in Neurology
- Light-to-moderate alcohol consumption may be associated with a reduced risk of incident overall dementia and Alzheimer’s Disease
- 3 months’ topiramate therapy for migraine prophylaxis decreases waist circumference, abdominal skinfold measurements, and body fat ratio
- For individuals with epilepsy, the risk having a broadly defined psychotic disorder is increased by 5.5-fold. The risk of having bipolar disorder is increased by 6.3-fold, and of having schizophrenia increases by 8.5-fold
Highlights in Neurology
Trans fat intake increases risk of ischemic stroke
In a study involving 87,025 postmenopausal women in the Women’s Health Initiative Observational Study, there were 1049 incident cases of ischemic stroke over 663,041 person-years of follow-up. Women in the highest quintile of trans fat intake were at increased risk of ischemic stroke (HR = 1.39) compared with women in the lowest quintile of trans fat intake. Aspirin use modulated the effect of trans fats; ASA users and ASA non-users had HRs for ischemic stroke of 0.95 and 1.66, respectively. Saturated, monounsaturated, and polyunsaturated fat intake were not associated with ischemic stroke.
Read the article summaryNew risk factors for chronic migraine identified
As published in the Journal of Neurological Sciences, increase tea consumption (> 4 cups/d), and diet consisting of hot and spicy foods, and weight gain increase the likelihood of chronicity in patients with episodic migraines. During a 12-month prospective study involving 188 patients with episodic migraines, 17.7% developed chronic, daily migraines. Other risk factors included low education, a high frequency of headaches, headaches of long duration, allodynia, and increased symptomatic treatment of headaches.
Read the article summaryGinsenoside-Rd improves outcomes in patients with acute ischemic stroke
In a randomized, double-blind, placebo-controlled trial, the calcium channel antagonist, ginsenoside-Rd, has been shown to improve functional outcomes in patients (n=386) with acute ischemic strokes. The patients received a 14-day infusion of ginsenoside-Rd within 72 hours of stroke onset. The National Institutes of Health Stroke Score was improved at 15 days and the modified Rankin score was improved at 90 days (OR = 1.74).
Read the article summaryMost Popular Neurology Articles
Last month's top read Top Articles of 20121 Three times weekly glatiramer acetate in relapsing-remitting multiple sclerosis Annals of Neurology , May 23, 2013
2 Comparative Effectiveness of Early Natalizumab Treatment in JC Virus'Negative Relapsing-Remitting Multiple Sclerosis The American Journal of Managed Care, May 6, 2013 Free full text Review Article
3 The magnetic resonance imaging rule of five: predicting the occurrence of relapse Multiple Sclerosis Journal, May 14, 2013
4 Dimethyl fumarate: a novel oral front-line therapy for multiple sclerosis treatment Future Neurology, May 28, 2013
5 The influence of vitamin D supplementation on melatonin status in patients with multiple sclerosis Brain, Behavior, and Immunity, May 14, 2013
6 The effects of long-term interferon- beta-1b treatment on cognitive functioning in multiple sclerosis: a 16-year longitudinal study Multiple Sclerosis Journal, May 10, 2013
7 Brain reserve and cognitive reserve in multiple sclerosis: What youve got and how you use it Neurology, May 15, 2013 Review Article
8 Eculizumab in AQP4-IgG-positive relapsing neuromyelitis optica spectrum disorders: an open-label pilot study The Lancet Neurology, May 20, 2013
9 Management of Secondary Progressive Multiple Sclerosis: Prophylactic Treatment--Past, Present, and Future Aspects Current Treatment Options in Neurology, May 13, 2013
10 Cognitive reserve and cortical atrophy in multiple sclerosis: A longitudinal study Neurology, May 1, 2013
11 Anti-JC virus antibody prevalence in a multinational multiple sclerosis cohort Multiple Sclerosis Journal, May 17, 2013
12 The effects of exercise training on fitness, mobility, fatigue, and health related quality of life among adults with multiple sclerosis: a systematic review to inform guideline development Archives of Physical Medicine and Rehabilitation, May 16, 2013 Evidence Based Medicine Review Article
13 The effect of vitamin D-related interventions on multiple sclerosis relapses: a meta-analysis Multiple Sclerosis Journal, May 30, 2013
14 Targeting B cells in the treatment of multiple sclerosis: recent advances and remaining challenges Therapeutic Advances in Neurological Disorders, April 15, 2013
15 Changing Associations Between Cognitive Impairment and Imaging in Multiple Sclerosis as the Disease Progresses The Journal of Neuropsychiatry & Clinical Neurosciences, May 21, 2013
16 The cost burden of multiple sclerosis in the United States: a systematic review of the literature Journal of Medical Economics , May 22, 2013
17 Comparison of ActiGraph activity monitors in persons with multiple sclerosis and controls Disability & Rehabilitation, May 3, 2013 Review Article
18 Consensus definitions and application guidelines for control groups in cerebrospinal fluid biomarker studies in multiple sclerosis Multiple Sclerosis Journal, May 24, 2013
19 The economic impact of multiple sclerosis in Australia in 2010 Multiple Sclerosis Journal, May 10, 2013
20 Clinical and biomarker assessment of demyelinating events suggesting multiple sclerosis Acta Neurologica Scandinavica, April 22, 2013
Indexed Journals in Neurology: Current Opinion in Neurology, Stroke, Seizure, Cephalgia, Brain Injury more
Other Topics in Neurology
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