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Neurology - Basic Science/Genetics News & Articles

What’s your first-line option for current Neurology information? MDLinx Neurology! Where else but MDLinx Neurology will you find subspecialty coverage of articles published on dementia, headache, movement disorders, neurologic oncology, neurosensory disorders, neurosurgery, pain medicine, pediatric neurology, sleep, spine and more? Also discover the latest clinical pearls from the Smartest Neurologist daily quiz competition and Neurology Physician Review. In less than five minutes a day, you can skim the summaries of pertinent articles within 24 hours of publication. Do you need the 2-minute update? Skip to the highlights from our physician editor, D. Scott Cunningham, MD, PhD, for the “can’t miss” summaries on hot topics in neurology and related subspecialties.

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Articles

Latest (4) Full Text Articles (450) Focus on Pediatric Neurology
Ranked, sorted, and summarized by MDLinx editors from the latest literature
Topics:

581 Nocturnal Eating/Drinking Syndrome With Restless Legs Syndrome Caused by Neuroleptics Improved by Yi-Gan San Add-on Treatment: A Case Report Clinical Neuropharmacology, January 22, 2013

582 Distinct Clinical Characteristics of C9orf72 Expansion Carriers Compared With GRN, MAPT, and Nonmutation Carriers in a Flanders-Belgian FTLD Cohort JAMA Neurology, January 22, 2013    Review Article

583 Attenuation of auditory N1 results from identity-specific action-effect prediction European Journal of Neuroscience, January 22, 2013    Review Article

584 Essential role of postsynaptic NMDA receptors in developmental refinement of excitatory synapses Proceedings of the National Academy of Sciences of the United States of America, January 21, 2013    Review Article

585 Blink-related momentary activation of the default mode network while viewing videos Proceedings of the National Academy of Sciences of the United States of America, January 21, 2013    Review Article

586 Striatal GABAergic and cortical glutamatergic neurons mediate contrasting effects of cannabinoids on cortical network synchrony Proceedings of the National Academy of Sciences of the United States of America, January 21, 2013    Review Article

587 Myc acts via the pten tumor suppressor to elicit autoregulation and genome-wide gene repression by activation of the ezh2 methyltransferase Cancer Research, January 21, 2013    Review Article

588 Mechanisms of action of naturally occurring antibodies against beta-amyloid on microglia Journal of Neuroinflammation, January 21, 2013    Review Article

589 Neuronal Nogo-A negatively regulates dendritic morphology and synaptic transmission in the cerebellum Proceedings of the National Academy of Sciences of the United States of America, January 18, 2013    Continuing Medical Education

590 Neuroligin-1 controls synaptic abundance of NMDA-type glutamate receptors through extracellular coupling Proceedings of the National Academy of Sciences of the United States of America, January 18, 2013    Review Article

591 S-nitrosylation of AMPA receptor GluA1 regulates phosphorylation, single-channel conductance, and endocytosis Proceedings of the National Academy of Sciences of the United States of America, January 18, 2013    Review Article

592 Disruption of Wild-Type IDH1 Suppresses D-2-Hydroxyglutarate Production in IDH1-Mutated Gliomas Cancer Research, January 18, 2013    Review Article

593 Expanding the phenotype associated with 17q12 duplication: Case report and review of the literature American Journal of Medical Genetics Part A, January 18, 2013

594 Neurofibromatosis type 2 in the elderly population: Clinical and molecular features American Journal of Medical Genetics Part A, January 18, 2013    Clinical Guideline

595 Neddylation pathway regulates T-cell function by targeting an adaptor protein Shc and a protein kinase Erk signaling Proceedings of the National Academy of Sciences of the United States of America, January 17, 2013    Review Article

596 Different effects of soluble and aggregated amyloid β42 on gene/protein expression and enzyme activity involved in insulin and APP pathways Journal of Neural Transmission, January 17, 2013    Review Article

597 Polarised Localisation of the Voltage-Gated Sodium Channel Nav1.2 in Cerebellar Granule Cells The Cerebellum, January 16, 2013    Review Article

598 The role of electrode location and stimulation polarity in patient response to cortical stimulation for major depressive disorder Brain Stimulation, January 16, 2013    Review Article

599 Aliphatic peptides show similar self-assembly to amyloid core sequences, challenging the importance of aromatic interactions in amyloidosis Proceedings of the National Academy of Sciences of the United States of America, January 16, 2013    Review Article

600 The Migration of Neural Progenitor Cell Mediated by SDF-1 is NF-κB/HIF-1α Dependent upon Hypoxia CNS Neuroscience & Therapeutics, January 15, 2013    Review Article

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Clinical Pearls in Neurology

Highlights in Neurology

Trans fat intake increases risk of ischemic stroke

In a study involving 87,025 postmenopausal women in the Women’s Health Initiative Observational Study, there were 1049 incident cases of ischemic stroke over 663,041 person-years of follow-up. Women in the highest quintile of trans fat intake were at increased risk of ischemic stroke (HR = 1.39) compared with women in the lowest quintile of trans fat intake. Aspirin use modulated the effect of trans fats; ASA users and ASA non-users had HRs for ischemic stroke of 0.95 and 1.66, respectively. Saturated, monounsaturated, and polyunsaturated fat intake were not associated with ischemic stroke.

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New risk factors for chronic migraine identified

As published in the Journal of Neurological Sciences, increase tea consumption (> 4 cups/d), and diet consisting of hot and spicy foods, and weight gain increase the likelihood of chronicity in patients with episodic migraines. During a 12-month prospective study involving 188 patients with episodic migraines, 17.7% developed chronic, daily migraines. Other risk factors included low education, a high frequency of headaches, headaches of long duration, allodynia, and increased symptomatic treatment of headaches.

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Ginsenoside-Rd improves outcomes in patients with acute ischemic stroke

In a randomized, double-blind, placebo-controlled trial, the calcium channel antagonist, ginsenoside-Rd, has been shown to improve functional outcomes in patients (n=386) with acute ischemic strokes. The patients received a 14-day infusion of ginsenoside-Rd within 72 hours of stroke onset. The National Institutes of Health Stroke Score was improved at 15 days and the modified Rankin score was improved at 90 days (OR = 1.74).

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Most Popular Neurology Articles

Last month's top read Top Articles of 2012

1 Characterization of the Huntington intermediate CAG repeat expansion phenotype in PHAROS Neurology, May 14, 2013

2 Neuronal Morphology Goes Digital: A Research Hub for Cellular and System Neuroscience Neuron, April 9, 2013    Review Article

3 Right but not left angular gyrus modulates the metric component of the mental body representation: a tDCS study Experimental Brain Research, May 30, 2013    Review Article

4 Impairment of mitochondrial dynamics: a target for the treatment of neurological disorders Future Neurology, May 28, 2013    Review Article

5 Differential Tangential Expansion as a Mechanism for Cortical Gyrification Cerebral Cortex, April 19, 2013    Review Article

6 Musicians Enhanced Neural Differentiation of Speech Sounds Arises Early in Life: Developmental Evidence from Ages 3 to 30 Cerebral Cortex, May 9, 2013    Review Article

7 8OHdG is not a biomarker for Huntington disease state or progression Neurology, May 14, 2013

8 The Ventral Hippocampus Is the Embryonic Origin for Adult Neural Stem Cells in the Dentate Gyrus Neuron, May 21, 2013    Review Article

9 The right anterior intraparietal sulcus is critical for bimanual grasping: a tms study Cerebral Cortex, May 23, 2013    Review Article

10 Directed Differentiation and Functional Maturation of Cortical Interneurons from Human Embryonic Stem Cells Cell Stem Cell, May 7, 2013    Review Article

11 The circulatory systemic environment as a modulator of neurogenesis and brain aging Autoimmunity Reviews, May 15, 2013    Review Article

12 Sympathetic regulation of cerebral blood flow in humans: a review British Journal of Anesthesia, April 26, 2013    Review Article

13 Development of human embryonic stem cell therapies for age-related macular degeneration Trends in Neurosciences, May 8, 2013    Review Article

14 Head injury and risk of Parkinson disease: A systematic review and meta-analysis Movement Disorders, May 13, 2013    Review Article

15 Phenotypic heterogeneity of the 8344A>G mtDNA MERRF mutation Neurology, May 3, 2013    Review Article

16 Rapid cell death is preceded by amyloid plaque-mediated oxidative stress Proceedings of the National Academy of Sciences of the United States of America, May 15, 2013    Review Article

17 The role of β-adrenergic blockers in parkinsons disease: possible genetic and cell-signaling mechanisms American Journal of Alzheimer's Disease and Other Dementias, May 23, 2013    Review Article

18 Hereditary sensory and autonomic neuropathy type 1 (HSANI) caused by a novel mutation in SPTLC2 Neurology, May 24, 2013    Review Article

19 Spinal muscular atrophy due to a de novo 1.3Mb deletion: Implication for genetic counseling Neuromuscular Disorders, May 2, 2013

20 Altered splicing of ATP6AP2 causes X-linked parkinsonism with spasticity (XPDS) Human Molecular Genetics, May 2, 2013    Review Article

Indexed Journals in Neurology: Current Opinion in Neurology, Stroke, Seizure, Cephalgia, Brain Injurymore

Other Topics in Neurology

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