We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1Combined lysis of thrombus with ultrasound and systemic tissue plasminogen activator for emergent revascularization in acute ischemic stroke (CLOTBUST-ER): design and methodology of a multinational phase 3 trialInternational Journal of Stroke, July 07, 2015  Clinical Article
2The effects of DL-3-n-butylphthalide in patients with vascular cognitive impairment no dementia caused by subcortical ischemic small vessel disease: A multicentre, randomized, double-blind, placebo-controlled trialAlzheimer's & Dementia, July 07, 2015  Clinical Article
3Dexamethasone exerts profound immunologic interference on treatment efficacy for recurrent glioblastomaBritish Journal of Cancer, July 07, 2015  Clinical Article
4Practice variability and efficacy of clonazepam, lorazepam, and midazolam in status epilepticus: A multicenter comparisonEpilepsia, July 07, 2015  Clinical Article
5Small brain lesions and incident stroke and mortality: a cohort studyAnnals of Internal Medicine, July 07, 2015  Clinical Article  Evidence Based Medicine
6Clinical outcomes in patients with Parkinson's disease treated with a monoamine oxidase type-B inhibitor: a cross-sectional, cohort studyPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, July 07, 2015  Clinical Article
7Rehab-let: touchscreen tablet for self-training impaired dexterity post stroke: study protocol for a pilot randomized controlled trialTrials, July 07, 2015  Full Text  Clinical Article
8Muscles and their role in episodic tension-type headache: implications for treatmentEuropean Journal of Pain, July 07, 2015  Clinical Article
9Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatmentNeuropharmacology, July 07, 2015  Clinical Article
10DWI and FLAIR imaging in herpes simplex encephalitis: A comparative and topographical analysisJournal of Neurology, July 07, 2015  Clinical Article

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We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1Study finds people over 65 with traumatic brain injuries are hospitalized almost four times as often as younger peopleSt. Michael's Hospital, July 07, 2015
2Commonly prescribed drugs affect decisions to harm oneself and othersUniversity College London New, July 07, 2015
3Tablet technology to help children with autismMonash University News, July 07, 2015
4How cortisol reinforces terrifying memoriesRuhr-Universitaet-Bochum News, July 07, 2015
5Research breakthrough to treat girls-only epilepsyThe University of Adelaide News, July 07, 2015
6Midlife changes in Alzheimer's biomarkers may predict dementiaWashington University School of Medicine in St. Louis News, July 07, 2015
7A new atlas of the brain opens up alternative means for studying brain disordersUniversity of the Basque Country News, July 07, 2015
8Fingolimod in RRMS: Indication of added benefit in certain patientsGerman Institute for Quality and Efficiency in Health Care (IQWiG), July 07, 2015
9New study again shows: More strokes with intracranial stentsGerman Institute for Quality and Efficiency in Health Care (IQWiG), July 07, 2015
10Brain imaging shows how children inherit their parents' anxietyUniversity of Wisconsin-Madison News, July 07, 2015

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Moderate exercise has a positive effect on DPN

As reported in Diabetes and Its Complications, moderate exercise (40%-60% heart rate reserve) for 8 weeks resulted in significant improvement in nerve conduction velocity (peroneal and sural nerves) in patients with T2DM and clinical neuropathy (n=87) as compared with standard care.

L-carnitine levels have clinical significance in non-APOE4 carriers with mild AD

As reported in the Journal of Alzheimer’s Disease, the CSF L-carnitine levels are decreased in patients with early Alzheimer’s disease (AD) who are non-APOE4 carriers. Further, the L-carnitine levels are correlated with Aβ42 and the MMSE score. It is suggested that L-carnitine supplementation may be beneficial in non-APOE4 carriers with mild AD.

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Clinical Pearls

Clinical Pearl from Smartest DocElderly cancer patients have a reduced risk of Alzheimer’s disease dementia and vice versa.

Clinical Pearl from Smartest DocPeripheral neuropathies are associated with an increase in cytokine expression.

Clinical Pearl from Smartest DocSerial quantification of HHV-6 DNA in CSF may be useful for successful treatment with ganciclovir in post-transplant HHV-6 encephalitis.