Nonapnea sleep disorders are associated with subsequent ischemic stroke risk: A nationwide, population-based, retrospective cohort study
Sleep Medicine,  Clinical Article

Huang WS, et al. – The objective of the study was to assess the association between nonapnea sleep disorders (NSD) and the risk for acute ischemic stroke among patients in Taiwan. The nationwide, population–based, retrospective cohort study provides evidence that patients with NSD were at increased risk for developing ischemic stroke compared to patients without diagnosed sleep disorder, with men and the elderly being at greatest risk.

Methods

  • The authors conducted the longitudinal nationwide, population–based, retrospective study using Taiwan’s National Health Insurance Research Database (NHIRD) from January 1997 to December 2001.
  • All study participants were followed until the incidence of ischemic stroke, or until censoring due to death; until withdrawal from the insurance program; or until they were lost to follow–up by the end of 2010.
  • Cox proportional hazard regression analysis was used to assess the association between NSD and subsequent ischemic stroke risk.

Results

  • They analyzed the data collected from 94,160 participants as a comparison cohort and 47,080 participants as a NSD cohort with the diagnosis date as the index date.
  • The age range of cohorts was 20.0–101.7years and 64% were women.
  • The average follow–up duration was 9.61years for the NSD cohort and 9.42years for the reference cohort.
  • Overall, the ischemic stroke incidence was 1.48–fold higher in the NSD cohort than in the reference cohort (8.87 vs 6.00/1000 individual–years), with an adjusted hazard ratio (HR) of 1.19 after controlling for age, sex, and comorbidities.
  • The study also showed a 1.35–fold significantly higher risk for developing ischemic stroke in men compared to women.
  • The adjusted HR was 31.2 for elderly patients compared with participants aged ≤35years.

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Neurology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Neurology Articles

1 Clopidogrel plus aspirin aspirin alone for preventing early neurological deterioration in patients with acute ischemic stroke Journal of Clinical Neuroscience, November 13, 2014    Clinical Article

2 Marijuana use associated with lower death rates in patients with traumatic brain injuries Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center News, November 11, 2014

3 Zolpidem and the risk of Parkinson's disease: A nationwide population-based study Journal of Psychiatric Research, August 1, 2014    Clinical Article

4 Effects of antiplatelet agents on functional outcome and cognitive status in patients with acute ischemic stroke Full Text International Journal of Gerontology, November 21, 2014    Free full text    Clinical Article

5 Efficacy and safety of novel oral anticoagulants in patients with cervical artery dissections Cerebrovascular Diseases, November 14, 2014    Clinical Article

6 Recurrent stroke in the warfarin versus aspirin in reduced cardiac ejection fraction (WARCEF) trial Cerebrovascular Diseases, October 16, 2014    Clinical Article

7 Long-term outcomes after stenting versus endarterectomy for treatment of symptomatic carotid stenosis: the International Carotid Stenting Study (ICSS) randomised trial The Lancet, October 17, 2014    Evidence Based Medicine    Clinical Article
Exclusive Author Commentary

8 Antithrombotic therapy after acute ischemic stroke in patients with atrial fibrillation Stroke, November 25, 2014    Clinical Article

9 Efficacy of HMG-CoA reductase inhibitors in the prevention of cerebrovascular attack in 1016 patients older than 75 years among 4014 type 2 diabetic individuals International Journal of Cardiology, November 7, 2014    Clinical Article

10 Menopausal hormone therapy and central nervous system tumor risk: Large UK prospective study and meta-analysis International Journal of Cancer, November 7, 2014    Evidence Based Medicine

11 Effects of golden hour thrombolysis a Prehospital Acute Neurological Treatment and Optimization of Medical Care in Stroke (PHANTOM-S) substudy JAMA Neurology, November 20, 2014    Clinical Article

12 Safety and efficacy of ceftriaxone for amyotrophic lateral sclerosis: A multi-stage, randomised, double-blind, placebo-controlled trial The Lancet Neurology, October 9, 2014    Clinical Article

13 The efficacy and safety of cilostazol in ischemic Stroke Patients with Peripheral Arterial Disease (SPAD): protocol of a randomized, double-blind, placebo-controlled multicenter trial International Journal of Stroke, November 18, 2014    Clinical Article

14 Neonatal vitamin D and childhood brain tumor risk International Journal of Cancer, November 17, 2014    Clinical Article

15 Emergency and critical care management of acute ischaemic stroke CNS Drugs, November 26, 2014    Clinical Article

16 Results of 2-year vitamin B treatment on cognitive performance: Secondary data from an RCT Neurology®, November 21, 2014    Clinical Article

17 Functional outcome after primary endovascular therapy or IV thrombolysis alone for stroke. an observational, comparative effectiveness study Cerebrovascular Diseases, November 24, 2014    Clinical Article

18 Dairy products and the risk of stroke and coronary heart disease: the Rotterdam Study European Journal of Nutrition, October 14, 2014    Clinical Article

19 Folate, vitamin B-6, and vitamin B-12 intake and mild cognitive impairment and probable dementia in the Women’s Health Initiative Memory Study Journal of the Academy of Nutrition and Dietetics, November 12, 2014    Clinical Article

20 The durability of endovascular coiling versus neurosurgical clipping of ruptured cerebral aneurysms: 18 year follow-up of the UK cohort of the International Subarachnoid Aneurysm Trial (ISAT) The Lancet, October 30, 2014    Evidence Based Medicine    Clinical Article

Indexed Journals in Neurology: Current Opinion in Neurology, Stroke, Seizure, Cephalgia, Brain Injurymore