Simultaneous retinal and cortical visually evoked electrophysiological responses in between migraine attacks
Nguyen BN et al. – This study finds normal retinal processing of flickering stimuli in the presence of abnormal cortical function between migraine attacks.Methods
- Monocular transient (1Hz) and steady–state (8.3Hz) pattern reversal electroretinograms (PERGs) and pattern visual evoked responses (PVERs) were measured simultaneously in 45 people with migraine (26 without aura, 19 with aura) and 30 non–headache controls at a time between migraine attacks.
- PERG amplitude and timing did not differ significantly between groups.
- Transient PVER amplitude was significantly reduced (28%) in the migraine with aura group compared to the controls F(2,72)=3.6, p=0.03).
- Both migraine groups showed significant reductions (32%, 39%) in steady–state PVER amplitude relative to controls (F(2,70)=4.3, p=0.02).