Effects of telmisartan on the cerebral circulation of hypertensive patients with chronic-stage stroke
Hypertension Research, 07/09/2012
Deguchi I et al. – Telmisartan showed good antihypertensive activity in hypertensive patients with chronic–stage stroke without affecting hemispheric blood flow, and it even increased regional cerebral blood flow (CBF) in most regions examined.Methods
- This prospective study examined the effects of telmisartan, an angiotensin II type I receptor blocker with peroxisome proliferator–activated receptor gamma agonistic action, on blood pressure (BP) control and cerebral circulation in hypertensive patients with chronic–stage stroke.
- Telmisartan (40 mg per day) was administered to 10 patients with systolic BP (SBP) 140 mm Hg and diastolic BP (DBP) 90 mm Hg at least 4 weeks after lacunar or atherothrombotic infarction.
- Casual BP and resting cerebral blood flow (CBF) were evaluated at baseline and week 12 using technetium–99 m ethyl cysteinate dimer single–photon emission computed tomography.
- Both SBP and DBP declined significantly from 156.4±17.0 to 127.4±6.6 mm Hg and 84.2±14.5 to 74.2±5.2 mm Hg, respectively (P<0.05).
- Mean CBF (mCBF) in both the left and right cerebral hemispheres did not change, and the mCBF of both the impaired and unimpaired sides of supratentorial lesion patients (n=6) did not change.
- Investigation of regional CBF in all patients revealed significant increases in the callosomarginal, precentral, central, parietal, temporal, posterior cerebral, lenticular nucleus, thalamic and hippocampal regions at week 12 (P<0.05).