Secreted phospholipase A2-IIA-induced a phenotype of activated microglia in BV-2 cells requires epidermal growth factor receptor transactivation and proHB-EGF shedding
Journal of Neuroinflammation, 07/05/2012
Martin R et al. – The results support the hypothesis that sPLA2–IIA may act as a potent modulator of microglial functions through its ability to induce EGFR transactivation and heparin–binding EGF–like growth factor (HB–EGF) release. Accordingly, pharmacological modulation of EGFR might be a useful tool for treating neuroinflammatory diseases characterized by sPLA2–IIA accumulation.