Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation
Journal of Neuroinflammation, 07/05/2012
van Horssen J et al. – The high frequency of preactive lesions suggests that it is unlikely that most of them will progress into full–blown demyelinating lesions. Preactive lesions are not associated with blood–brain barrier disruption, suggesting that an intrinsic trigger of innate immune activation, rather than extrinsic factors crossing a damaged blood–brain barrier, induces the formation of clusters of activated microglia.