Clinical and neurobiological correlates of soluble amyloid precursor proteins in the cerebrospinal fluid
Alzheimer's & Dementia, 07/11/2012
Alexopoulos P et al. – The positive correlation between sAPPalpha and sAPPbeta challenges the hypothesis that AD is caused by an imbalance of the alpha– and beta–secretase APP proteolysis through competing mechanisms. Moreover, the differences in CSF levels of sAPPalpha and sAPPbeta between male and female patients with AD may reflect a “sexual dimorphism” in the activity of the two APP processing pathways in AD.