The neuroprotective effects of milk fat globule-EGF factor 8 against oligomeric amyloid β toxicity
Journal of Neuroinflammation, 06/29/2012
Li E et al. – The results suggest that microglia release MFG–E8 in response to signals from degenerated neurons and that MFG–E8 protects oAbeta–induced neuronal cell death by promoting microglial phagocytic activity and activating the Nrf2–HO–1 pathway. Thus, MFG–E8 may have novel roles as a neuroprotectant in neurodegenerative conditions.