Therapeutic approaches for HER2-positive brain metastases: Circumventing the blood-brain barrier
Cancer Treatment Reviews, 06/29/2012
Mehta AI et al. – Available data suggest that trastuzumab extends survival in patients with HER2–positive MBC and brain metastasis. Novel methods for delivery of therapeutic agents into the brain could be used in the future to enhance access to the central nervous system (CNS) by trastuzumab, thereby improving its efficacy in this setting.