Tumor-Associated Microglia/Macrophages Enhance the Invasion of Glioma Stem-like Cells via TGF-{beta}1 Signaling Pathway
The Journal of Immunology, 06/21/2012
Ye XZ et al. – The results demonstrate that tumor–associated microglia/macrophages (TAM/Ms) enhance the invasiveness of CD133+glioma stem–like cells (GSLCs) via the release of TGF–β1, which increases the production of MMP–9 by GSLCs. Therefore, the TGF–β1 signaling pathway is a potential therapeutic target for limiting the invasiveness of GSLCs.



