Impact of polyunsaturated fatty acid consumption prior to ischemic stroke
Acta Neurologica Scandinavica, 07/02/2012
Clinical Article
Mishina M et al. – High eicosapentaenoic acid (EPA)/arachidonic acid (AA) ratio was associated with good outcome in ischemic stroke. The paper suggests that prestroke dietary habits affect the severity in patients with ischemic stroke.
Methods- The authors studied 75 patients with lacunar infarction (LI; n=25), atherothrombotic infarction (AT; n=32), and cardiogenic embolism (CE; n=18).
- The patients underwent blood examinations in a fasting state next morning of hospitalization, including examination of low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), triglyceride (TG), blood glucose, hemoglobin A1c (HbA1c), uric acid, and fatty acid fractions of EPA, DHA, dihomo-γ-linolenic acid (DGLA), and arachidonic acid (AA).
- They used the modified Rankin Scale (mRS) to assess clinical severity at discharge.
- There was no significant difference in the EPA/AA and DHA/AA ratio among the three stroke subgroups, although the DGLA/AA ratio was significantly higher in patients with LI than in patients with CE.
- Considering the confounding factors, the mRS was negatively correlated with EPA/AA and positively correlated with age, DHA/AA, and blood glucose.
