Psilocybin dose-dependently causes delayed, transient headaches in healthy volunteers

Drug and Alcohol Dependence, 05/29/2012

The data suggest that headache is an adverse event to be expected with the nonmedical use of psilocybin–containing mushrooms as well as the administration of psilocybin in human research.

Methods

  • This double-blind study examined a broad range of psilocybin doses (0, 5, 10, 20, and 30mg/70kg) on headache in 18 healthy participants.

Results

  • Psilocybin frequently caused headache, the incidence, duration, and severity of which increased in a dose-dependent manner.
  • All headaches had delayed onset, were transient, and lasted no more than a day after psilocybin administration.

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