Visual cortex excitability and plasticity associated with remission from chronic to episodic migraine
Cephalalgia, 04/27/2012Chen WT et al.
The pattern of P100m responses to consecutive stimulation changes with the transition from chronic migraine (CM) to episodic migraine (EM). Visual cortex plasticity might be a potential biomarker reflecting clinical remission of CM.
At baseline, 25 patients with CM were studied interictally.
For each patient, 30 sequential blocks of 50 P100m responses were obtained by MEG.
Sub–averaged amplitudes at blocks 2, 9, 16, 23 and 30 were further compared with that at block 1 to assess response habituation or potentiation (i.e. significant decrease or increase at either block vs block 1).
The same study was repeated in those patients who remitted from CM to EM after topiramate treatment.
In total, 10 CM patients remitted to EM after treatment.
In the follow–up study of these patients during the interictal stage, the P100m at block 1 decreased in amplitude from 53.6±6.6nAm before remission to 43.0±5.1nAm (p=0.028), and the responses at subsequent blocks switched from habituation (amplitude block 30block 1, p=0.028).
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