Evidence-based guideline update: Pharmacologic treatment for episodic migraine prevention in adults
Neurology, 05/15/2012  Clinical Article

Silberstein SD et al. – Frovatriptan is effective for prevention of menstrual migraine (Level A). Lamotrigine is ineffective for migraine prevention (Level A).

• The authors analyzed published studies from June 1999 to May 2009 using a structured review process to classify the evidence relative to the efficacy of various medications available in the United States for migraine prevention.

• The author panel reviewed 284 abstracts, which ultimately yielded 29 Class I or Class II articles that are reviewed herein.
• Divalproex sodium, sodium valproate, topiramate, metoprolol, propranolol, and timolol are effective for migraine prevention and should be offered to patients with migraine to reduce migraine attack frequency and severity (Level A).