p75 neurotrophin receptor signaling in nervous system injury and degeneration: paradox and opportunity
Trends in Neurosciences, 05/08/2012
Ibanez CF et al. – A series of studies during the past decade has demonstrated that p75NTR signaling contributes to neuronal and glial cell damage, axonal degeneration and dysfunction during injury and cellular stress. Why the nervous system reacts to injury by inducing a molecule that aids the demise of cells and axons is a biological paradox that remains to be explained satisfactorily.