How Statins Could be Evaluated Successfully in Clinical Trials for Alzheimer’s Disease
American Journal of Alzheimer's Disease and Other Dementias, 04/23/2012
Burgos JS et al. – The authors consider that there are a number of explanations for this failure that may provide guidance for selecting and clinically developing statins with therapeutic efficacy in Alzheimer’s disease (AD).
- Over the last decade, a large number of experimental observations have suggested a relationship between alterations in cholesterol homeostasis and Alzheimer’s disease (AD).
- Moreover, epidemiological studies have pointed an association between statin treatment and a decrease in the risk of having AD.
- For these reasons, a large number of clinical trials have been carried out to determine whether the statins can prevent the progression of AD.
- However, these studies did not provide clear evidence for the therapeutic efficacy in AD.