Effects of telmisartan on cognition and regional cerebral blood flow in hypertensive patients with Alzheimers disease
Geriatrics and Gerontology International,  Clinical Article

Kume K et al. – The findings suggest that telmisartan may have additional benefits and be useful for the treatment of elderly hypertensive patients with Alzheimer's disease (AD).

Methods
  • A total of 20 patients with probable AD and essential hypertension were randomly assigned to the telmisartan group (n=10, 40-80 mg daily) or the amlodipine group (n=10, 5-10 mg daily) for 6 months.

Results
  • The groups had a similar significant reduction in systolic and diastolic blood pressure after treatment.
  • The telmisartan group did not show any changes in cognitive function test scores, while the amlodipine group showed significantly higher scores on the AD Assessment Scale-Cognitive Subscale (Japanese version).
  • Analysis of covariance to analyze treatment effect revealed that the telmisartan group showed increased rCBF in the right supramarginal gyrus, superior parietal lobule, cuneus, and lingual gyrus compared with the amlodipine group, while the amlodipine group showed increased rCBF only in the right cingulate gyrus compared with the telmisartan group at 6 months.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

    Currently, there are no available articles.

Your Unread Messages in Neurology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Neurology Articles

Indexed Journals in Neurology: Current Opinion in Neurology, Stroke, Seizure, Cephalgia, Brain Injurymore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close