Intrathecal levels of vitamin D and IgG in multiple sclerosis
Acta Neurologica Scandinavica, 04/30/2012
Clinical Article
Holmoy T et al. – Physiological variation in vitamin D does not exert a major impact on intrathecal synthesis of IgG in multiple sclerosis (MS).
Methods- To investigate the relation between vitamin D levels in cerebrospinal fluid and serum and intrathecal synthesis of IgG.
- 25-hydroxyvitamin D (25(OH)D) and IgG were assessed in cerebrospinal fluid and serum in 40 patients with MS.
- There was no significant correlation between the IgG index and 25(OH)D levels in cerebrospinal fluid or serum.
- The levels of 25(OH)D in cerebrospinal fluid and serum did not differ between patients with and without intrathecal synthesis of IgG.
- There was a non-significant trend towards a positive correlation between the concentrations of 25(OH)D and IgG in the cerebrospinal fluid, but not in serum.
