Parasympathetic alteration during sub-clinical seizures
Seizure - European Journal of Epilepsy,  Clinical Article

Brotherstone R et al. – The pilot study indicates that parasympathetic changes occur during sub–clinical seizures. Generalised sub–clinical seizures may be associated with more autonomic instability compared to temporal lobe sub–clinical seizures.

Methods
  • A prospective study based on Video-electroencephalography (EEG)/electrocardiography (ECG)/oxygen saturation (SAO2) recordings was selected from patients having sub-clinical seizures during stage 3 or 4 sleep.
  • The authors analysed R–R intervals in the ECG from 1-min prior to the electrographic onset to the end of sub-clinical seizures.
  • Matched non-ictal R–R baseline measurements were selected from stages 3 or 4 sleep.
  • R–R interval data were analysed using NeuroScope software providing a cardiac index of parasympathetic activity (CIPA).
  • BioSignal short-term heart rate variability (HRV) software was used to analyse the same R–R interval data previously analysed using NeuroScope except that sub-clinical seizure data was embedded within 5-min epochs and compared to 5-min epochs of non-ictal measurements.

Results
  • A total of 33 sub-clinical seizures were recorded from 11 patients comprising 19 generalised sub-clinical seizures (2 patients), 9 right temporal lobe sub-clinical seizures (5 patients) and 5 left temporal lobe sub-clinical seizures (4 patients) were compared to matched non-ictal measurements.
  • Parasympathetic activity was clearly altered during total sub-clinical seizures in terms of the CIPA (p<0.001) and 5-min HRV high frequency (HF) % (p=0.026) measures.
  • Generalised sub-clinical seizures resulted in increased cardiac parasympathetic activity whereas temporal lobe seizures were associated with a decrease in parasympathetic activity.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Neurology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Neurology Articles

1 Consumption of nuts and legumes and risk of stroke: a meta-analysis of prospective cohort studies Nutrition, Metabolism & Cardiovascular Diseases, July 28, 2014    Evidence Based Medicine    Clinical Article

2 Clopidogrel plus aspirin versus warfarin in patients with stroke and aortic arch plaques Stroke, May 2, 2014    Clinical Article

3 Comparing the efficacy and safety of Crocus sativus L. with memantine in patients with moderate to severe Alzheimer's disease: A double-blind randomized clinical trial Human Psychopharmacology: Clinical and Experimental, July 15, 2014    Clinical Article

4 Tozadenant (SYN115) in patients with Parkinson's disease who have motor fluctuations on levodopa: A phase 2b, double-blind, randomised trial The Lancet Neurology, July 7, 2014    Clinical Article

5 Role of traditional nonsteroidal anti-inflammatory drugs in Alzheimer's disease: A meta-analysis of randomized clinical trials American Journal of Alzheimer's Disease and Other Dementias, July 16, 2014    Clinical Article

6 Patent foramen ovale closure versus medical therapy for stroke prevention: meta analysis of randomized trials and review of heterogeneity in meta analyses Canadian Journal of Cardiology, June 2, 2014    Evidence Based Medicine    Review Article    Clinical Article

7 Efficacy and safety of donepezil, galantamine, rivastigmine, and memantine for the treatment of Alzheimer's disease: A systematic review and meta-analysis Journal of Alzheimer’s Disease, April 2, 2014    Evidence Based Medicine    Review Article    Clinical Article

8 A prospective open-label study of sirolimus for the treatment of anti-Hu associated paraneoplastic neurological syndromes Neuro-Oncology, July 8, 2014    Clinical Article

9 Risk of stroke associated with nonsteroidal anti-inflammatory drugs Full Text Vascular Health and Risk Management, January 13, 2014    Free full text    Review Article    Clinical Article

10 Consumption of nuts and legumes and risk of incident ischemic heart disease, stroke, and diabetes: a systematic review and meta-analysis American Journal of Clinical Nutrition, June 19, 2014    Evidence Based Medicine    Review Article

11 Should oral anticoagulants be restarted after warfarin-associated cerebral haemorrhage in patients with atrial fibrillation? Thrombosis and Haemostasis, January 17, 2014    Clinical Article

12 Stroke and cerebrovascular diseases in patients with chronic kidney disease The Lancet Neurology, July 17, 2014    Clinical Article

13 Association between orthostatic hypotension and cardiovascular risk, cerebrovascular risk, cognitive decline and falls as well as overall mortality: a systematic review and meta-analysis Journal of Hypertension, July 14, 2014

14 Modification of outcomes with aspirin or apixaban in relation to female and male sex in patients with atrial fibrillation Stroke, July 11, 2014    Clinical Article

15 Long term cerebral and vascular complications after irradiation of the neck in head and neck cancer patients: A prospective cohort study: study rationale and protocol Full Text BMC Neurology, July 1, 2014    Free full text    Clinical Article

16 The use of intravenous magnesium sulphate for acute migraine: meta-analysis of randomized controlled trials European Journal of Emergency Medicine, January 10, 2014    Evidence Based Medicine    Review Article    Clinical Article

17 Migraine, white matter hyperintensities, and subclinical brain infarction in a diverse community Stroke, June 13, 2014    Evidence Based Medicine    Clinical Article

18 Stroke incidence and mortality trends in US communities, 1987 to 2011 JAMA, July 18, 2014    Evidence Based Medicine    Clinical Article

19 Predicting outcomes of neuroreflexotherapy in patients with subacute or chronic neck or low back pain The Spine Journal, July 29, 2014    Clinical Article

20 Immunotherapy for brain cancer: recent progress and future promise Clinical Cancer Research, July 3, 2014    Clinical Article

Indexed Journals in Neurology: Current Opinion in Neurology, Stroke, Seizure, Cephalgia, Brain Injurymore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close