IM Seizure Medication Effective for Status Epilepticus Full Text
Emergency Medicine News,

Talan J – The study was designed to ensure that antiseizure medicines delivered through an autoinjector were not inferior to the IV approach. The primary outcome was the absence of seizures by the time they arrived at the emergency department. Secondary outcomes included endotracheal intubation, recurrent seizures, and the timing of treatment relative to when the prolonged seizures stopped.

Methods
  • Paramedics throughout the country were trained in the study protocol so they could decide whether a seizing patient was a candidate for the clinical study.
  • Enrollment was so smooth, study investigators said, that they had all of the patients they needed a year earlier than expected.

Results
  • The RAMPART investigators found that 73.4 percent of patients (329 of 448) in the group that received midazolam through the autoinjector were seizure-free by the time they reached the hospital compared with 63.4 percent (282 of 445) of those who were randomized to receive IV lorazepam (p<0.001 for noninferiority and superiority).

Please login or register to follow this author.
► Click here to access Full Text, PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Neurology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Neurology Articles

1 Clopidogrel plus aspirin aspirin alone for preventing early neurological deterioration in patients with acute ischemic stroke Journal of Clinical Neuroscience, November 13, 2014    Clinical Article

2 Marijuana use associated with lower death rates in patients with traumatic brain injuries Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center News, November 11, 2014

3 Zolpidem and the risk of Parkinson's disease: A nationwide population-based study Journal of Psychiatric Research, August 1, 2014    Clinical Article

4 Effects of antiplatelet agents on functional outcome and cognitive status in patients with acute ischemic stroke Full Text International Journal of Gerontology, November 21, 2014    Free full text    Clinical Article

5 Efficacy and safety of novel oral anticoagulants in patients with cervical artery dissections Cerebrovascular Diseases, November 14, 2014    Clinical Article

6 Recurrent stroke in the warfarin versus aspirin in reduced cardiac ejection fraction (WARCEF) trial Cerebrovascular Diseases, October 16, 2014    Clinical Article

7 Long-term outcomes after stenting versus endarterectomy for treatment of symptomatic carotid stenosis: the International Carotid Stenting Study (ICSS) randomised trial The Lancet, October 17, 2014    Evidence Based Medicine    Clinical Article
Exclusive Author Commentary

8 Antithrombotic therapy after acute ischemic stroke in patients with atrial fibrillation Stroke, November 25, 2014    Clinical Article

9 Efficacy of HMG-CoA reductase inhibitors in the prevention of cerebrovascular attack in 1016 patients older than 75 years among 4014 type 2 diabetic individuals International Journal of Cardiology, November 7, 2014    Clinical Article

10 Menopausal hormone therapy and central nervous system tumor risk: Large UK prospective study and meta-analysis International Journal of Cancer, November 7, 2014    Evidence Based Medicine

11 Effects of golden hour thrombolysis a Prehospital Acute Neurological Treatment and Optimization of Medical Care in Stroke (PHANTOM-S) substudy JAMA Neurology, November 20, 2014    Clinical Article

12 Safety and efficacy of ceftriaxone for amyotrophic lateral sclerosis: A multi-stage, randomised, double-blind, placebo-controlled trial The Lancet Neurology, October 9, 2014    Clinical Article

13 The efficacy and safety of cilostazol in ischemic Stroke Patients with Peripheral Arterial Disease (SPAD): protocol of a randomized, double-blind, placebo-controlled multicenter trial International Journal of Stroke, November 18, 2014    Clinical Article

14 Neonatal vitamin D and childhood brain tumor risk International Journal of Cancer, November 17, 2014    Clinical Article

15 Emergency and critical care management of acute ischaemic stroke CNS Drugs, November 26, 2014    Clinical Article

16 Results of 2-year vitamin B treatment on cognitive performance: Secondary data from an RCT Neurology®, November 21, 2014    Clinical Article

17 Functional outcome after primary endovascular therapy or IV thrombolysis alone for stroke. an observational, comparative effectiveness study Cerebrovascular Diseases, November 24, 2014    Clinical Article

18 Dairy products and the risk of stroke and coronary heart disease: the Rotterdam Study European Journal of Nutrition, October 14, 2014    Clinical Article

19 Folate, vitamin B-6, and vitamin B-12 intake and mild cognitive impairment and probable dementia in the Women’s Health Initiative Memory Study Journal of the Academy of Nutrition and Dietetics, November 12, 2014    Clinical Article

20 The durability of endovascular coiling versus neurosurgical clipping of ruptured cerebral aneurysms: 18 year follow-up of the UK cohort of the International Subarachnoid Aneurysm Trial (ISAT) The Lancet, October 30, 2014    Evidence Based Medicine    Clinical Article

Indexed Journals in Neurology: Current Opinion in Neurology, Stroke, Seizure, Cephalgia, Brain Injurymore