Association of antibiotics with status epilepticus
Neurological Sciences,  Clinical Article

Misra UK et al. – The findings suggest that the antibiotic should be carefully chosen in patients with hepatic and renal failure, and the dose should be modified.

Methods
  • In a retrospective review, 12 out of 117 (10%) patients with SE had temporal association with antibiotic administration.
  • Their medical history, clinical findings, and duration and type of SE were recorded.
  • Serum chemistry, blood counts, cranial MRI, EEG and CSF examination were carried out.
  • The offending antibiotics were withdrawn and the patients were treated with phenytoin, lorazepam, sodium valproate or midazolam.
  • The response to treatment was recorded and death during hospital stay noted.
  • The median age of the patients was 36 (18 and 74) years and 5 were females.

Results
  • Eight patients had convulsive and four nonconvulsive SE.
  • The median duration of status was 12 h.
  • The antibiotics related to SE included intravenous cephalosporin (ceftazidime 5, amoxyclavulenic acid 2, piperacillin 2, cefepime and quinolones (levofloxacin 3, ofloxacin 1, ciprofloxacin in isolation or in combinations.
  • Five patients had hepatic (41.7%) and 6 (50%) renal failure; the later received higher than the recommended dose of antibiotics.
  • Cranial MRI was abnormal in 7 out of 9 (77.8%) patients that include cortical lesion in one, corticosubcortical in three and subcortical in three.
  • SE responded to first antiepileptic drug in four and to second in five patients.
  • Three patients (25%) had refractory SE.
  • Eight (66.7%) patients died and death was related to SE in 2 patients.
  • 10% SE patients may be related to antibiotics.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Neurology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Neurology Articles

1 Consumption of nuts and legumes and risk of stroke: a meta-analysis of prospective cohort studies Nutrition, Metabolism & Cardiovascular Diseases, July 28, 2014    Evidence Based Medicine    Clinical Article

2 Clopidogrel plus aspirin versus warfarin in patients with stroke and aortic arch plaques Stroke, May 2, 2014    Clinical Article

3 Comparing the efficacy and safety of Crocus sativus L. with memantine in patients with moderate to severe Alzheimer's disease: A double-blind randomized clinical trial Human Psychopharmacology: Clinical and Experimental, July 15, 2014    Clinical Article

4 Tozadenant (SYN115) in patients with Parkinson's disease who have motor fluctuations on levodopa: A phase 2b, double-blind, randomised trial The Lancet Neurology, July 7, 2014    Clinical Article

5 Role of traditional nonsteroidal anti-inflammatory drugs in Alzheimer's disease: A meta-analysis of randomized clinical trials American Journal of Alzheimer's Disease and Other Dementias, July 16, 2014    Clinical Article

6 Patent foramen ovale closure versus medical therapy for stroke prevention: meta analysis of randomized trials and review of heterogeneity in meta analyses Canadian Journal of Cardiology, June 2, 2014    Evidence Based Medicine    Review Article    Clinical Article

7 Efficacy and safety of donepezil, galantamine, rivastigmine, and memantine for the treatment of Alzheimer's disease: A systematic review and meta-analysis Journal of Alzheimer’s Disease, April 2, 2014    Evidence Based Medicine    Review Article    Clinical Article

8 A prospective open-label study of sirolimus for the treatment of anti-Hu associated paraneoplastic neurological syndromes Neuro-Oncology, July 8, 2014    Clinical Article

9 Risk of stroke associated with nonsteroidal anti-inflammatory drugs Full Text Vascular Health and Risk Management, January 13, 2014    Free full text    Review Article    Clinical Article

10 Consumption of nuts and legumes and risk of incident ischemic heart disease, stroke, and diabetes: a systematic review and meta-analysis American Journal of Clinical Nutrition, June 19, 2014    Evidence Based Medicine    Review Article

11 Should oral anticoagulants be restarted after warfarin-associated cerebral haemorrhage in patients with atrial fibrillation? Thrombosis and Haemostasis, January 17, 2014    Clinical Article

12 Stroke and cerebrovascular diseases in patients with chronic kidney disease The Lancet Neurology, July 17, 2014    Clinical Article

13 Association between orthostatic hypotension and cardiovascular risk, cerebrovascular risk, cognitive decline and falls as well as overall mortality: a systematic review and meta-analysis Journal of Hypertension, July 14, 2014

14 Modification of outcomes with aspirin or apixaban in relation to female and male sex in patients with atrial fibrillation Stroke, July 11, 2014    Clinical Article

15 Long term cerebral and vascular complications after irradiation of the neck in head and neck cancer patients: A prospective cohort study: study rationale and protocol Full Text BMC Neurology, July 1, 2014    Free full text    Clinical Article

16 The use of intravenous magnesium sulphate for acute migraine: meta-analysis of randomized controlled trials European Journal of Emergency Medicine, January 10, 2014    Evidence Based Medicine    Review Article    Clinical Article

17 Migraine, white matter hyperintensities, and subclinical brain infarction in a diverse community Stroke, June 13, 2014    Evidence Based Medicine    Clinical Article

18 Stroke incidence and mortality trends in US communities, 1987 to 2011 JAMA, July 18, 2014    Evidence Based Medicine    Clinical Article

19 Predicting outcomes of neuroreflexotherapy in patients with subacute or chronic neck or low back pain The Spine Journal, July 29, 2014    Clinical Article

20 Immunotherapy for brain cancer: recent progress and future promise Clinical Cancer Research, July 3, 2014    Clinical Article

Indexed Journals in Neurology: Current Opinion in Neurology, Stroke, Seizure, Cephalgia, Brain Injurymore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close