Association of antibiotics with status epilepticus
Neurological Sciences,  Clinical Article

Misra UK et al. – The findings suggest that the antibiotic should be carefully chosen in patients with hepatic and renal failure, and the dose should be modified.

Methods
  • In a retrospective review, 12 out of 117 (10%) patients with SE had temporal association with antibiotic administration.
  • Their medical history, clinical findings, and duration and type of SE were recorded.
  • Serum chemistry, blood counts, cranial MRI, EEG and CSF examination were carried out.
  • The offending antibiotics were withdrawn and the patients were treated with phenytoin, lorazepam, sodium valproate or midazolam.
  • The response to treatment was recorded and death during hospital stay noted.
  • The median age of the patients was 36 (18 and 74) years and 5 were females.

Results
  • Eight patients had convulsive and four nonconvulsive SE.
  • The median duration of status was 12 h.
  • The antibiotics related to SE included intravenous cephalosporin (ceftazidime 5, amoxyclavulenic acid 2, piperacillin 2, cefepime and quinolones (levofloxacin 3, ofloxacin 1, ciprofloxacin in isolation or in combinations.
  • Five patients had hepatic (41.7%) and 6 (50%) renal failure; the later received higher than the recommended dose of antibiotics.
  • Cranial MRI was abnormal in 7 out of 9 (77.8%) patients that include cortical lesion in one, corticosubcortical in three and subcortical in three.
  • SE responded to first antiepileptic drug in four and to second in five patients.
  • Three patients (25%) had refractory SE.
  • Eight (66.7%) patients died and death was related to SE in 2 patients.
  • 10% SE patients may be related to antibiotics.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Neurology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Neurology Articles

1 Consumption of nuts and legumes and risk of stroke: a meta-analysis of prospective cohort studies Nutrition, Metabolism & Cardiovascular Diseases, July 28, 2014    Evidence Based Medicine    Clinical Article

2 Patent foramen ovale closure versus medical therapy for stroke prevention: meta analysis of randomized trials and review of heterogeneity in meta analyses Canadian Journal of Cardiology, August 7, 2014    Evidence Based Medicine    Review Article    Clinical Article

3 Intracranial hemorrhage mortality in atrial fibrillation patients treated with dabigatran or warfarin Stroke, August 14, 2014    Clinical Article

4 Supplementation of folic acid and vitamin B12 reduces plasma levels of asymmetric dimethylarginine in patients with acute ischemic stroke Journal of Clinical Neuroscience, August 18, 2014    Clinical Article

5 Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials The Lancet, August 11, 2014    Evidence Based Medicine    Clinical Article

6 Modification of outcomes with aspirin or apixaban in relation to female and male sex in patients with atrial fibrillation Stroke, July 11, 2014    Clinical Article

7 Treatment of relapsing-remitting multiple sclerosis after 24 doses of natalizumab JAMA Neurology, July 18, 2014    Clinical Article

8 Clopidogrel plus aspirin versus warfarin in patients with stroke and aortic arch plaques Stroke, May 2, 2014    Clinical Article

9 New concepts in the management of diffuse low-grade glioma: Proposal of a multistage and individualized therapeutic approach Neuro-Oncology, August 4, 2014    Clinical Article

10 Risk predictors of stroke and mortality following ablation for atrial fibrillation: The California experience 2005-2009 Heart Rhythm, August 1, 2014    Clinical Article

11 Zolpidem and the risk of Parkinson's disease: A nationwide population-based study Journal of Psychiatric Research, August 1, 2014    Clinical Article

12 Antiepileptics in migraine prophylaxis: An updated Cochrane review Cephalalgia, August 14, 2014    Clinical Article

13 Comparing the efficacy and safety of Crocus sativus L. with memantine in patients with moderate to severe Alzheimer's disease: A double-blind randomized clinical trial Human Psychopharmacology: Clinical and Experimental, July 15, 2014    Clinical Article

14 Medication-overuse headache: a review Full Text Journal of Pain Research, July 2, 2014    Free full text    Review Article

15 Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): A multicentre, randomised, open-label, phase 3 trial The Lancet Oncology, August 26, 2014    Clinical Article

16 Role of traditional nonsteroidal anti-inflammatory drugs in Alzheimer's disease: A meta-analysis of randomized clinical trials American Journal of Alzheimer's Disease and Other Dementias, July 16, 2014    Clinical Article

17 Reirradiation of recurrent medulloblastoma Cancer, August 1, 2014    Clinical Article

18 Temozolomide after radiotherapy in recurrent low grade diffuse brainstem glioma in adults Journal of Neuro-Oncology, August 21, 2014    Clinical Article

19 Lacunar strokes in patients with diabetes mellitus: risk factors, infarct location, and prognosis Stroke, August 26, 2014    Clinical Article

20 Low testosterone and the risk of dementia in elderly men Alzheimer's & Dementia, July 30, 2014    Clinical Article

Indexed Journals in Neurology: Current Opinion in Neurology, Stroke, Seizure, Cephalgia, Brain Injurymore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close