A randomised, double blind, placebo controlled trial with vitamin D3 as an add on treatment to interferon {beta}-1b in patients with multiple sclerosis
Journal of Neurology, Neurosurgery & Psychiatry, Exclusive Author Commentary  Clinical Article

Soilu–Hanninen M et al. – Vitamin D3 add on treatment to interferon β–1b (IFNB) reduces MRI disease activity in multiple sclerosis (MS).

Methods
  • 1 year, double blind, placebo controlled, randomised study in 66 MS patients.
  • The primary outcomes were T2 burden of disease (BOD) on MRI scans, proportion of patients with serum levels of 25-hydroxyvitamin D (25(OH)D) ≥85 nmol/l or intact parathyroid hormone (PTH) ≤20 ng/l, and number of adverse events.
  • Secondary outcomes were number of MRI enhancing T1 lesions and new T2 lesions, annual relapse rate, changes in the Expanded Disability Status Scale score, timed 25 foot walk test and timed 10 foot tandem walk tests.

Results
  • Median change in BOD was 287 mm3 in the placebo group and 83 mm3 in the vitamin D group (p=0.105).
  • Serum levels of 25(OH)D increased from a mean of 54 (range 19–82) nmol/l to 110 (range 67–163) nmol/l in the vitamin D group. 84% of patients reached a serum 25(OH)D level >85 nmol/l in the vitamin D group and 3% in the placebo group (p<0.0001).
  • Patients in the vitamin D group showed fewer new T2 lesions (p=0.286) and a significantly lower number of T1 enhancing lesions (p=0.004), as well as a tendency to reduced disability accumulation (p=0.071) and to improved timed tandem walk (p=0.076).
  • There were no significant differences in adverse events or in the annual relapse rate.

Our paper is the first randomised double-blind placebo controlled trial with vitamin D3 in MS patients with MRI outcomes. The most important results was the statistically significant reduction on Gd+ lesion in the vitamin D3 treated patients in comparison with the placebo group as well as the trends in MRI BOD, EDSS and timed tandem walk test. Our patients had active MS with an ARR of 0.51 before the trial onset and all of them were using interferon-beta 1b. It is possible that interferon-beta and vitamin D3 have a synergistic effects in MS. This is one explanation for the discrepancy with the negative results from another RCT (Kampman et al, Multiple sclerosis Epub ahead of print Feb 2012.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Neurology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Neurology Articles

1 Clopidogrel plus aspirin versus warfarin in patients with stroke and aortic arch plaques Stroke, May 2, 2014    Clinical Article

2 Consumption of nuts and legumes and risk of incident ischemic heart disease, stroke, and diabetes: a systematic review and meta-analysis American Journal of Clinical Nutrition, June 19, 2014    Evidence Based Medicine    Review Article

3 Patent foramen ovale closure versus medical therapy for stroke prevention: meta analysis of randomized trials and review of heterogeneity in meta analyses Canadian Journal of Cardiology, June 2, 2014    Evidence Based Medicine    Review Article    Clinical Article

4 Migraine, white matter hyperintensities, and subclinical brain infarction in a diverse community Stroke, June 13, 2014    Evidence Based Medicine    Clinical Article

5 Management of acute stroke in patients taking novel oral anticoagulants International Journal of Stroke, June 6, 2014    Clinical Article

6 Omega-3 fatty acids moderate effects of physical activity on cognitive function Neuropsychologia, June 9, 2014    Clinical Article

7 Efficacy and safety of donepezil, galantamine, rivastigmine, and memantine for the treatment of Alzheimer's disease: A systematic review and meta-analysis Journal of Alzheimer’s Disease, April 2, 2014    Evidence Based Medicine    Review Article    Clinical Article

8 Vitamin D and subclinical cerebrovascular disease the atherosclerosis risk in communities brain magnetic resonance imaging study JAMA Neurology, June 11, 2014    Clinical Article

9 Benzoate, a D-amino acid oxidase inhibitor, for the treatment of early-phase Alzheimer's disease: A randomized, double-blind, placebo-controlled trial Biological Psychiatry, April 4, 2014    Clinical Article
Exclusive Author Commentary

10 Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectives The Lancet, June 23, 2014    Review Article    Clinical Article

11 Stroke prevention in atrial fibrillation: established oral anticoagulants versus novel anticoagulants--translating clinical trial data into practice Journal of Interventional Cardiac Electrophysiology , June 5, 2014    Clinical Article

12 Fruits and vegetables consumption and risk of stroke Stroke, May 28, 2014    Evidence Based Medicine

13 Maternal dietary intake of folate and vitamins B6 and B12 during pregnancy and risk of childhood brain tumors Nutrition and Cancer, June 17, 2014    Clinical Article

14 The ASCOMALVA (association between the cholinesterase inhibitor donepezil and the cholinergic precursor choline alphoscerate in Alzheimer's disease) trial: Interim results after two years of treatment Journal of Alzheimer’s Disease, June 4, 2014    Clinical Article

15 Orolingual angioedema after alteplase therapy of acute ischaemic stroke: incidence and risk of prior angiotensin-converting enzyme inhibitor use European Journal of Neurology, June 10, 2014    Clinical Article

16 Should oral anticoagulants be restarted after warfarin-associated cerebral haemorrhage in patients with atrial fibrillation? Thrombosis and Haemostasis, January 17, 2014    Clinical Article

17 Clinical evolution of Parkinson's disease and prognostic factors affecting motor progression: 9-year follow-up study European Journal of Neurology, June 3, 2014    Clinical Article

18 The use of intravenous magnesium sulphate for acute migraine: meta-analysis of randomized controlled trials European Journal of Emergency Medicine, January 10, 2014    Evidence Based Medicine    Review Article    Clinical Article

19 Risk of stroke associated with nonsteroidal anti-inflammatory drugs Full Text Vascular Health and Risk Management, January 13, 2014    Free full text    Review Article    Clinical Article

20 Which drug should we use for stroke prevention in atrial fibrillation Current Opinion in Cardiology, June 9, 2014    Clinical Article

Indexed Journals in Neurology: Current Opinion in Neurology, Stroke, Seizure, Cephalgia, Brain Injurymore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close