Vitamin D insufficiency and mild cognitive impairment: cross-sectional association
European Journal of Neurology,  Clinical Article

Annweiler C et al. – Low 25OHD concentrations were associated with mild cognitive impairment (MCI) status in older non–demented community–dwellers with subjective memory complaint.

Methods
  • Ninety-five non-demented Caucasian community-dwellers with subjective memory complaint (mean, 71.1 ± 6.4 years; 54.7% women) included in the Gait and Alzheimer Interaction Tracking (GAIT) study were categorized into two groups.
  • Serum 25OHD concentration was divided into quartiles, the fourth quartile corresponding to the highest 25OHD concentration.
  • The cross-sectional associations between 25OHD concentrations and MCI were modeled using logistic regressions.
  • Age, gender, body mass index, number of comorbidities, education level, Mini-Mental State Examination score, Frontal Assessment Battery score, Geriatric Depression Scale score, creatinine clearance, and season tested were considered as potential confounders.

Results
  • Compared to CHI, patients with MCI (n = 43; mean, 71.4 ± 5.6 years; 34.9% women) had lower mean serum 25OHD concentrations (P = 0.006) and belonged more often to the lower quartiles compared to the highest quartile (P = 0.03).
  • Increased serum 25OHD concentration was associated with a lower risk of MCI [adjusted odds ratio (OR) = 0.96, P = 0.002].
  • Accordingly, lower quartiles of 25OHD were positively associated with MCI whilst using the highest quartile as reference (adjusted OR = 25.46, P = 0.002 for the first quartile; adjusted OR = 6.89, P = 0.03 for the second quartile; and adjusted OR = 10.29, P = 0.02 for the third quartile).

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Neurology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Neurology Articles

1 Clopidogrel plus aspirin versus warfarin in patients with stroke and aortic arch plaques Stroke, May 2, 2014    Clinical Article

2 Consumption of nuts and legumes and risk of incident ischemic heart disease, stroke, and diabetes: a systematic review and meta-analysis American Journal of Clinical Nutrition, June 19, 2014    Evidence Based Medicine    Review Article

3 Patent foramen ovale closure versus medical therapy for stroke prevention: meta analysis of randomized trials and review of heterogeneity in meta analyses Canadian Journal of Cardiology, June 2, 2014    Evidence Based Medicine    Review Article    Clinical Article

4 Migraine, white matter hyperintensities, and subclinical brain infarction in a diverse community Stroke, June 13, 2014    Evidence Based Medicine    Clinical Article

5 Management of acute stroke in patients taking novel oral anticoagulants International Journal of Stroke, June 6, 2014    Clinical Article

6 Omega-3 fatty acids moderate effects of physical activity on cognitive function Neuropsychologia, June 9, 2014    Clinical Article

7 Efficacy and safety of donepezil, galantamine, rivastigmine, and memantine for the treatment of Alzheimer's disease: A systematic review and meta-analysis Journal of Alzheimer’s Disease, April 2, 2014    Evidence Based Medicine    Review Article    Clinical Article

8 Vitamin D and subclinical cerebrovascular disease the atherosclerosis risk in communities brain magnetic resonance imaging study JAMA Neurology, June 11, 2014    Clinical Article

9 Benzoate, a D-amino acid oxidase inhibitor, for the treatment of early-phase Alzheimer's disease: A randomized, double-blind, placebo-controlled trial Biological Psychiatry, April 4, 2014    Clinical Article
Exclusive Author Commentary

10 Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectives The Lancet, June 23, 2014    Review Article    Clinical Article

11 Stroke prevention in atrial fibrillation: established oral anticoagulants versus novel anticoagulants--translating clinical trial data into practice Journal of Interventional Cardiac Electrophysiology , June 5, 2014    Clinical Article

12 Fruits and vegetables consumption and risk of stroke Stroke, May 28, 2014    Evidence Based Medicine

13 Maternal dietary intake of folate and vitamins B6 and B12 during pregnancy and risk of childhood brain tumors Nutrition and Cancer, June 17, 2014    Clinical Article

14 The ASCOMALVA (association between the cholinesterase inhibitor donepezil and the cholinergic precursor choline alphoscerate in Alzheimer's disease) trial: Interim results after two years of treatment Journal of Alzheimer’s Disease, June 4, 2014    Clinical Article

15 Orolingual angioedema after alteplase therapy of acute ischaemic stroke: incidence and risk of prior angiotensin-converting enzyme inhibitor use European Journal of Neurology, June 10, 2014    Clinical Article

16 Should oral anticoagulants be restarted after warfarin-associated cerebral haemorrhage in patients with atrial fibrillation? Thrombosis and Haemostasis, January 17, 2014    Clinical Article

17 Clinical evolution of Parkinson's disease and prognostic factors affecting motor progression: 9-year follow-up study European Journal of Neurology, June 3, 2014    Clinical Article

18 The use of intravenous magnesium sulphate for acute migraine: meta-analysis of randomized controlled trials European Journal of Emergency Medicine, January 10, 2014    Evidence Based Medicine    Review Article    Clinical Article

19 Risk of stroke associated with nonsteroidal anti-inflammatory drugs Full Text Vascular Health and Risk Management, January 13, 2014    Free full text    Review Article    Clinical Article

20 Which drug should we use for stroke prevention in atrial fibrillation Current Opinion in Cardiology, June 9, 2014    Clinical Article

Indexed Journals in Neurology: Current Opinion in Neurology, Stroke, Seizure, Cephalgia, Brain Injurymore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close