Vitamin D insufficiency and mild cognitive impairment: cross-sectional association
European Journal of Neurology,  Clinical Article

Annweiler C et al. – Low 25OHD concentrations were associated with mild cognitive impairment (MCI) status in older non–demented community–dwellers with subjective memory complaint.

Methods
  • Ninety-five non-demented Caucasian community-dwellers with subjective memory complaint (mean, 71.1 ± 6.4 years; 54.7% women) included in the Gait and Alzheimer Interaction Tracking (GAIT) study were categorized into two groups.
  • Serum 25OHD concentration was divided into quartiles, the fourth quartile corresponding to the highest 25OHD concentration.
  • The cross-sectional associations between 25OHD concentrations and MCI were modeled using logistic regressions.
  • Age, gender, body mass index, number of comorbidities, education level, Mini-Mental State Examination score, Frontal Assessment Battery score, Geriatric Depression Scale score, creatinine clearance, and season tested were considered as potential confounders.

Results
  • Compared to CHI, patients with MCI (n = 43; mean, 71.4 ± 5.6 years; 34.9% women) had lower mean serum 25OHD concentrations (P = 0.006) and belonged more often to the lower quartiles compared to the highest quartile (P = 0.03).
  • Increased serum 25OHD concentration was associated with a lower risk of MCI [adjusted odds ratio (OR) = 0.96, P = 0.002].
  • Accordingly, lower quartiles of 25OHD were positively associated with MCI whilst using the highest quartile as reference (adjusted OR = 25.46, P = 0.002 for the first quartile; adjusted OR = 6.89, P = 0.03 for the second quartile; and adjusted OR = 10.29, P = 0.02 for the third quartile).

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