Assessment of dementia risk in aging adults using both FDG-PET and FDDNP-PET imaging

International Journal of Geriatric Psychiatry, 03/16/2012

The fluoro–d–glucose–positron emission tomography (PET) data provided independent validation that different patterns of 2–(1–{6–[(2–[F–18]fluoroethyl)(methyl)amino]–2–naphthyl}ethylidene)malononitrile (FDDNP)–PET binding in non–demented individuals may be associated with differential dementia risk.


  • Fifty-four subjects with normal aging (N = 28) or amnestic forms of mild cognitive impairment (N = 26) underwent FDDNP-PET and FDG-PET scanning.
  • Subjects in the LG, HF/PA, and HT/PC FDDNP subgroups were compared according to visual ratings, statistical parametric mapping, and automated region of interest analyses of their FDG-PET data.


  • The FDDNP-PET subgroups demonstrated different glucose metabolic patterns according to visual ratings, region of interest, and statistical parametric mapping analyses of FDG-PET data.
  • The LG FDDNP subgroup showed no areas of significant hypometabolism relative to the other subgroups and had low Alzheimer's disease risk by FDG-PET standards.
  • The HF/PA FDDNP subgroup demonstrated hypometabolism in bilateral inferior parietal/parietotemporal, bilateral posterior cingulate, perisylvian, mid-temporal gyrus, and dorsolateral prefrontal regions, which is a pattern suggestive of high Alzheimer's disease risk.
  • The HT/PC FDDNP subgroup demonstrated heterogeneous FDG-PET patterns with predominant anterior frontal and anterior temporal hypometabolism, suggestive of mixed etiologies, including fronto-temporal dementia risk.

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