Chitinase enzyme activity in CSF is a powerful biomarker of Alzheimer disease
Neurology®,  Clinical Article

Watabe–Rudolph M et al. – Taken together, the findings in this study provide experimental evidence that DNA damage markers are significantly increased in Alzheimer disease (AD) and non–AD dementia. The biomarkers identified outperformed the standard CSF markers for diagnosing AD and non–AD dementia in the cohort investigated.

Methods
  • Here, the authors analyzed the level of novel biomarkers of DNA damage and telomere dysfunction (chitinase activity, N-acetyl-glucosaminidase activity, stathmin, and EF-1 α) in CSF of 94 patients with AD, 41 patients with non-AD dementia, and 40 control patients without dementia.

Results
  • Enzymatic activity of chitinase (chitotriosidase activity) and stathmin protein level were significantly increased in CSF of patients with AD and non-AD dementia compared with that of no dementia control patients.
  • As a single marker, chitinase activity was most powerful for distinguishing patients with AD from no dementia patients with an accuracy of 85.8% using a single threshold.
  • Discrimination was even superior to clinically standard CSF markers that showed an accuracy of 78.4% (β-amyloid) and 77.6% (tau).
  • Combined analysis of chitinase with other markers increased the accuracy to a maximum of 91%.
  • The biomarkers of DNA damage were also increased in CSF of patients with non-AD dementia compared with no dementia patients, and the new biomarkers improved the diagnosis of non-AD dementia as well as the discrimination of AD from non-AD dementia.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Neurology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Neurology Articles

1 Clopidogrel plus aspirin versus warfarin in patients with stroke and aortic arch plaques Stroke, May 2, 2014    Clinical Article

2 Consumption of nuts and legumes and risk of incident ischemic heart disease, stroke, and diabetes: a systematic review and meta-analysis American Journal of Clinical Nutrition, June 19, 2014    Evidence Based Medicine    Review Article

3 Patent foramen ovale closure versus medical therapy for stroke prevention: meta analysis of randomized trials and review of heterogeneity in meta analyses Canadian Journal of Cardiology, June 2, 2014    Evidence Based Medicine    Review Article    Clinical Article

4 Migraine, white matter hyperintensities, and subclinical brain infarction in a diverse community Stroke, June 13, 2014    Evidence Based Medicine    Clinical Article

5 Management of acute stroke in patients taking novel oral anticoagulants International Journal of Stroke, June 6, 2014    Clinical Article

6 Omega-3 fatty acids moderate effects of physical activity on cognitive function Neuropsychologia, June 9, 2014    Clinical Article

7 Efficacy and safety of donepezil, galantamine, rivastigmine, and memantine for the treatment of Alzheimer's disease: A systematic review and meta-analysis Journal of Alzheimer’s Disease, April 2, 2014    Evidence Based Medicine    Review Article    Clinical Article

8 Vitamin D and subclinical cerebrovascular disease the atherosclerosis risk in communities brain magnetic resonance imaging study JAMA Neurology, June 11, 2014    Clinical Article

9 Benzoate, a D-amino acid oxidase inhibitor, for the treatment of early-phase Alzheimer's disease: A randomized, double-blind, placebo-controlled trial Biological Psychiatry, April 4, 2014    Clinical Article
Exclusive Author Commentary

10 Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectives The Lancet, June 23, 2014    Review Article    Clinical Article

11 Stroke prevention in atrial fibrillation: established oral anticoagulants versus novel anticoagulants--translating clinical trial data into practice Journal of Interventional Cardiac Electrophysiology , June 5, 2014    Clinical Article

12 Fruits and vegetables consumption and risk of stroke Stroke, May 28, 2014    Evidence Based Medicine

13 Maternal dietary intake of folate and vitamins B6 and B12 during pregnancy and risk of childhood brain tumors Nutrition and Cancer, June 17, 2014    Clinical Article

14 The ASCOMALVA (association between the cholinesterase inhibitor donepezil and the cholinergic precursor choline alphoscerate in Alzheimer's disease) trial: Interim results after two years of treatment Journal of Alzheimer’s Disease, June 4, 2014    Clinical Article

15 Orolingual angioedema after alteplase therapy of acute ischaemic stroke: incidence and risk of prior angiotensin-converting enzyme inhibitor use European Journal of Neurology, June 10, 2014    Clinical Article

16 Should oral anticoagulants be restarted after warfarin-associated cerebral haemorrhage in patients with atrial fibrillation? Thrombosis and Haemostasis, January 17, 2014    Clinical Article

17 Clinical evolution of Parkinson's disease and prognostic factors affecting motor progression: 9-year follow-up study European Journal of Neurology, June 3, 2014    Clinical Article

18 The use of intravenous magnesium sulphate for acute migraine: meta-analysis of randomized controlled trials European Journal of Emergency Medicine, January 10, 2014    Evidence Based Medicine    Review Article    Clinical Article

19 Risk of stroke associated with nonsteroidal anti-inflammatory drugs Full Text Vascular Health and Risk Management, January 13, 2014    Free full text    Review Article    Clinical Article

20 Which drug should we use for stroke prevention in atrial fibrillation Current Opinion in Cardiology, June 9, 2014    Clinical Article

Indexed Journals in Neurology: Current Opinion in Neurology, Stroke, Seizure, Cephalgia, Brain Injurymore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close