The Atorvastatin During Ischemic Stroke Study: A Pilot Randomized Controlled Trial
Clinical Neuropharmacology,  Clinical Article

Muscari A et al. – This pilot study was unable to show any short–term benefit of atorvastatin during the acute phase of ischemic stroke. However, it suggested a possible favorable functional effect at 3 months in the least severe strokes, which could be the primary end point for a future multicenter trial.

Methods
  • 62 patients with ischemic stroke, aged 75.3 (SD, ±11.9) years (68% women), were randomized into a placebo (n = 31) and an atorvastatin 80 mg/d (n = 31) group.
  • Double–blind treatment lasted 7 days.
  • Primary end point was a decrease of National Institutes of Health Stroke Scale score of 4 points or higher after 7 days.
  • Infarct volume measured on computed tomographic scan after 3 days and a modified Rankin Scale of less than 2 at 3 months were secondary end points.

Results
  • There was no difference in the primary end point between the 2 groups (odds ratio, atorvastatin vs placebo, 0.74; 95% confidence interval, 0.26–2.17).
  • Infarct volume also was similar in the 2 groups.
  • Instead, there were more patients with modified Rankin Scale of less than 2 at 3 months in the atorvastatin than in the placebo group (adjusted odds ratio, 6.7; 95% confidence interval, 1.0–45.0; P = 0.05).
  • This prevalence concerned only the subgroup with mild strokes (National Institutes of Health Stroke Scale, ≤10; 53.8% vs 15.4%, respectively; P = 0.04).
  • Atorvastatin was well tolerated.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Neurology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Neurology Articles

1 Consumption of nuts and legumes and risk of stroke: a meta-analysis of prospective cohort studies Nutrition, Metabolism & Cardiovascular Diseases, July 28, 2014    Evidence Based Medicine    Clinical Article

2 Clopidogrel plus aspirin versus warfarin in patients with stroke and aortic arch plaques Stroke, May 2, 2014    Clinical Article

3 Comparing the efficacy and safety of Crocus sativus L. with memantine in patients with moderate to severe Alzheimer's disease: A double-blind randomized clinical trial Human Psychopharmacology: Clinical and Experimental, July 15, 2014    Clinical Article

4 Tozadenant (SYN115) in patients with Parkinson's disease who have motor fluctuations on levodopa: A phase 2b, double-blind, randomised trial The Lancet Neurology, July 7, 2014    Clinical Article

5 Role of traditional nonsteroidal anti-inflammatory drugs in Alzheimer's disease: A meta-analysis of randomized clinical trials American Journal of Alzheimer's Disease and Other Dementias, July 16, 2014    Clinical Article

6 Patent foramen ovale closure versus medical therapy for stroke prevention: meta analysis of randomized trials and review of heterogeneity in meta analyses Canadian Journal of Cardiology, June 2, 2014    Evidence Based Medicine    Review Article    Clinical Article

7 Efficacy and safety of donepezil, galantamine, rivastigmine, and memantine for the treatment of Alzheimer's disease: A systematic review and meta-analysis Journal of Alzheimer’s Disease, April 2, 2014    Evidence Based Medicine    Review Article    Clinical Article

8 A prospective open-label study of sirolimus for the treatment of anti-Hu associated paraneoplastic neurological syndromes Neuro-Oncology, July 8, 2014    Clinical Article

9 Risk of stroke associated with nonsteroidal anti-inflammatory drugs Full Text Vascular Health and Risk Management, January 13, 2014    Free full text    Review Article    Clinical Article

10 Consumption of nuts and legumes and risk of incident ischemic heart disease, stroke, and diabetes: a systematic review and meta-analysis American Journal of Clinical Nutrition, June 19, 2014    Evidence Based Medicine    Review Article

11 Should oral anticoagulants be restarted after warfarin-associated cerebral haemorrhage in patients with atrial fibrillation? Thrombosis and Haemostasis, January 17, 2014    Clinical Article

12 Stroke and cerebrovascular diseases in patients with chronic kidney disease The Lancet Neurology, July 17, 2014    Clinical Article

13 Association between orthostatic hypotension and cardiovascular risk, cerebrovascular risk, cognitive decline and falls as well as overall mortality: a systematic review and meta-analysis Journal of Hypertension, July 14, 2014

14 Modification of outcomes with aspirin or apixaban in relation to female and male sex in patients with atrial fibrillation Stroke, July 11, 2014    Clinical Article

15 Long term cerebral and vascular complications after irradiation of the neck in head and neck cancer patients: A prospective cohort study: study rationale and protocol Full Text BMC Neurology, July 1, 2014    Free full text    Clinical Article

16 The use of intravenous magnesium sulphate for acute migraine: meta-analysis of randomized controlled trials European Journal of Emergency Medicine, January 10, 2014    Evidence Based Medicine    Review Article    Clinical Article

17 Migraine, white matter hyperintensities, and subclinical brain infarction in a diverse community Stroke, June 13, 2014    Evidence Based Medicine    Clinical Article

18 Stroke incidence and mortality trends in US communities, 1987 to 2011 JAMA, July 18, 2014    Evidence Based Medicine    Clinical Article

19 Predicting outcomes of neuroreflexotherapy in patients with subacute or chronic neck or low back pain The Spine Journal, July 29, 2014    Clinical Article

20 Immunotherapy for brain cancer: recent progress and future promise Clinical Cancer Research, July 3, 2014    Clinical Article

Indexed Journals in Neurology: Current Opinion in Neurology, Stroke, Seizure, Cephalgia, Brain Injurymore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close