The Atorvastatin During Ischemic Stroke Study: A Pilot Randomized Controlled Trial
Clinical Neuropharmacology,  Clinical Article

Muscari A et al. – This pilot study was unable to show any short–term benefit of atorvastatin during the acute phase of ischemic stroke. However, it suggested a possible favorable functional effect at 3 months in the least severe strokes, which could be the primary end point for a future multicenter trial.

Methods
  • 62 patients with ischemic stroke, aged 75.3 (SD, ±11.9) years (68% women), were randomized into a placebo (n = 31) and an atorvastatin 80 mg/d (n = 31) group.
  • Double–blind treatment lasted 7 days.
  • Primary end point was a decrease of National Institutes of Health Stroke Scale score of 4 points or higher after 7 days.
  • Infarct volume measured on computed tomographic scan after 3 days and a modified Rankin Scale of less than 2 at 3 months were secondary end points.

Results
  • There was no difference in the primary end point between the 2 groups (odds ratio, atorvastatin vs placebo, 0.74; 95% confidence interval, 0.26–2.17).
  • Infarct volume also was similar in the 2 groups.
  • Instead, there were more patients with modified Rankin Scale of less than 2 at 3 months in the atorvastatin than in the placebo group (adjusted odds ratio, 6.7; 95% confidence interval, 1.0–45.0; P = 0.05).
  • This prevalence concerned only the subgroup with mild strokes (National Institutes of Health Stroke Scale, ≤10; 53.8% vs 15.4%, respectively; P = 0.04).
  • Atorvastatin was well tolerated.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Neurology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Neurology Articles

1 Consumption of nuts and legumes and risk of stroke: a meta-analysis of prospective cohort studies Nutrition, Metabolism & Cardiovascular Diseases, July 28, 2014    Evidence Based Medicine    Clinical Article

2 Patent foramen ovale closure versus medical therapy for stroke prevention: meta analysis of randomized trials and review of heterogeneity in meta analyses Canadian Journal of Cardiology, August 7, 2014    Evidence Based Medicine    Review Article    Clinical Article

3 Intracranial hemorrhage mortality in atrial fibrillation patients treated with dabigatran or warfarin Stroke, August 14, 2014    Clinical Article

4 Supplementation of folic acid and vitamin B12 reduces plasma levels of asymmetric dimethylarginine in patients with acute ischemic stroke Journal of Clinical Neuroscience, August 18, 2014    Clinical Article

5 Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials The Lancet, August 11, 2014    Evidence Based Medicine    Clinical Article

6 Modification of outcomes with aspirin or apixaban in relation to female and male sex in patients with atrial fibrillation Stroke, July 11, 2014    Clinical Article

7 Treatment of relapsing-remitting multiple sclerosis after 24 doses of natalizumab JAMA Neurology, July 18, 2014    Clinical Article

8 Clopidogrel plus aspirin versus warfarin in patients with stroke and aortic arch plaques Stroke, May 2, 2014    Clinical Article

9 New concepts in the management of diffuse low-grade glioma: Proposal of a multistage and individualized therapeutic approach Neuro-Oncology, August 4, 2014    Clinical Article

10 Risk predictors of stroke and mortality following ablation for atrial fibrillation: The California experience 2005-2009 Heart Rhythm, August 1, 2014    Clinical Article

11 Zolpidem and the risk of Parkinson's disease: A nationwide population-based study Journal of Psychiatric Research, August 1, 2014    Clinical Article

12 Antiepileptics in migraine prophylaxis: An updated Cochrane review Cephalalgia, August 14, 2014    Clinical Article

13 Comparing the efficacy and safety of Crocus sativus L. with memantine in patients with moderate to severe Alzheimer's disease: A double-blind randomized clinical trial Human Psychopharmacology: Clinical and Experimental, July 15, 2014    Clinical Article

14 Medication-overuse headache: a review Full Text Journal of Pain Research, July 2, 2014    Free full text    Review Article

15 Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): A multicentre, randomised, open-label, phase 3 trial The Lancet Oncology, August 26, 2014    Clinical Article

16 Role of traditional nonsteroidal anti-inflammatory drugs in Alzheimer's disease: A meta-analysis of randomized clinical trials American Journal of Alzheimer's Disease and Other Dementias, July 16, 2014    Clinical Article

17 Reirradiation of recurrent medulloblastoma Cancer, August 1, 2014    Clinical Article

18 Temozolomide after radiotherapy in recurrent low grade diffuse brainstem glioma in adults Journal of Neuro-Oncology, August 21, 2014    Clinical Article

19 Lacunar strokes in patients with diabetes mellitus: risk factors, infarct location, and prognosis Stroke, August 26, 2014    Clinical Article

20 Low testosterone and the risk of dementia in elderly men Alzheimer's & Dementia, July 30, 2014    Clinical Article

Indexed Journals in Neurology: Current Opinion in Neurology, Stroke, Seizure, Cephalgia, Brain Injurymore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close