Risk Factors and Preventive Interventions for Alzheimer Disease: State of the Science
JAMA Neurology, 05/11/2011
Daviglus ML et al. – Currently, insufficient evidence exists to draw firm conclusions on the association of any modifiable factors with risk of Alzheimer disease(AD).Methods
- Study inclusion criteria for the evidence report were participants aged 50 years and older from general populations in developed countries.
- Minimum sample sizes of 300 for cohort studies and 50 for randomized controlled trials.
- At least 2 years between exposure and outcome assessment; and use of well–accepted diagnostic criteria for AD.
- Included studies were evaluated for eligibility and data were ed.
- Quality of overall evidence for each factor was summarized as low, moderate, or high.
- Diabetes mellitus, hyperlipidemia in midlife, and current tobacco use were associated with increased risk of AD, and Mediterranean–type diet, folic acid intake, low or moderate alcohol intake, cognitive activities, and physical activity were associated with decreased risk.
- Quality of evidence was low for all of these associations.