Statin use and outcome after intracerebral hemorrhage- Case-control study and meta-analysis
Biffi A et al. – Antecedent use of statins prior to Intracerebral hemorrhage(ICH) is associated with favorable outcome and reduced mortality after ICH. This phenomenon appears to be a class effect of statins.Methods
- 90–day functional outcome in 238 pre–ICH statin cases and 461 statin–free ICH cases were compared in this prospectively ascertained cohort.
- Cohort were then meta–analyzed along with previously published studies using a random effects model, for a total of 698 ICH statin cases and 1,823 non–statin–exposed subjects.
- Data from the center demonstrated an association between statin use before ICH and increased probability of favorable outcome (odds ratio [OR]=2.08, 95% confidence interval [CI] 1.37–3.17) and reduced mortality (OR=0.47, 95% CI 0.32–0.70) at 90 days.
- No compound–specific statin effect was identified.
- Meta–analysis of all published evidence confirmed the effect of statin use on good outcome (OR=1.91, 95% CI 1.38–2.65) and mortality (OR=0.55, 95% CI 0.42–0.72) after ICH.