Measurement of blood–brain barrier permeability in acute ischemic stroke using standard first-pass perfusion CT data

NeuroImage: Clinical, 06/14/2013

The purpose of this study is to develop a method that yields the correct blood–brain barrier permeability value using first–pass perfusion CT data. The authors have developed a method of estimating blood–brain barrier permeability using first–pass perfusion CT data. This predictive method allows reliable blood–brain barrier permeability estimation within standard acquisition time, minimizing the likelihood of motion artefacts thereby improving image quality and reducing radiation dose.


  • The authors acquired 43 CT perfusion datasets, comprising experimental (n = 30) and validation subject groups (n = 13).
  • The Gjedde–Patlak method was used to estimate blood–brain barrier permeability using first-pass (30–60 s after contrast administration) and delayed phase (30–200 s) data.
  • In the experimental group, linear regression was used to obtain a function predicting first-pass blood–brain barrier permeability estimates from delayed phase estimates in each stroke compartment.
  • The reliability of prediction with this function was then tested using data from the validation group.


  • The predicted delayed phase blood–brain barrier permeability was strongly correlated with the measured delayed phase value (r = 0.67 and 0.6 for experimental and validation group respectively; p < 0.01).
  • Predicted and measured delayed phase blood–brain barrier permeability in each stroke compartment were not significantly different in both experimental and validation groups.

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