Directly observed treatment, short course in tuberculous meningitis: Indian perspective

Annals of the Indian Academy of Neurology, 03/01/2013

The authors did a prospective study to assess effectiveness of Revised National TB Control Program (RNTCP–DOTS) regimes among tuberculous meningitis (TBM) patients. The authors found intermitted short course chemotherapy was effective in TBM.


  • In this study the authors include the TBM patients admitted from September 2008 to March 2011.
  • All were referred to RNTCP for treatment.
  • Diagnostic Algorithm as per RNTCP guidelines was strictly followed and treatment outcome and follow-up status were recorded.
  • The authors exclude HIV and pediatric age group.


  • A total of 42 cases registered for DOTS regimen were included in the study, of which 35 completed the treatment (83%).
  • All the patients were started with DOTS but finally 78% received actual DOTS.
  • All patients were given 9 months intermitted regimen as per RNTCP guidelines.
  • Seven patients died during the treatment (16%).

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