Short latency afferent inhibition in Parkinsons disease patients with dementia

Movement Disorders, 06/08/2012

The findings add further evidence that differential cholinergic deficiency occurs in Parkinson's disease (PD) and PD dementia (PDD). Short-latency afferent inhibition (SAI)can be a neurophysiological correlate of PDD.


  • SAI and neuropsychological profile were studied in nondemented PD, PDD, Alzheimer's disease (AD) patients, and age-matched controls.


  • SAI was significantly impaired in AD cases (94.7 ± 6.2 versus 55.5 ± 4.0; P<0.0001).
  • In PD patients, it was not different from controls (61.4 ± 5.8 versus 55.5 ± 4.0; P=0.412).
  • PDD cases demonstrated a significant impairment in SAI (91.4 ± 5.2 versus 55.5 ± 4.0; P<0.0001).
  • A high correlation was found between SAI and Mini–Mental State Examination (r=-0.68; P<0.0001).

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