Progressive Axonal Dysfunction Precedes Development of Neuropathy in Type 2 Diabetes
Diabetes, 05/11/2012Sung JY et al.
These results suggest a spectrum of excitability abnormalities in patients with diabetes and that early axonal dysfunction may be detected prior to the development of neuropathy. As progressive changes in excitability parameters correlated to neuropathy severity, excitability testing may provide a biomarker of the early development and severity of diabetic neuropathy, providing insights into the pathophysiological mechanisms producing axonal dysfunction.
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