Mechanisms underlying the impairment of hippocampal long-term potentiation and memory in experimental Parkinson’s disease

Brain, 05/09/2012

Interestingly, the dopamine precursor L–DOPA was able to restore hippocampal synaptic potentiation via D1/D5 receptors and to ameliorate the cognitive deficit in parkinsonian experimental models suggesting that dopamine–dependent impairment of hippocampal long–term potentiation may contribute to cognitive deficits in patients with Parkinson’s disease.

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