Anti-NMDA-receptor antibody detected in encephalitis, schizophrenia, and narcolepsy with psychotic features
BMC Psychiatry, 05/09/2012Tsutsui K et al.
In addition to 3 typical cases, the authors found 7 cases with anti–NMDA receptor antibody associated with various psychotic and sleep symptoms, which lack any noticeable clinical signs of encephalitis throughout the course of the disease episodes.
The study included a total of 61 patients from age 15 to 61 and was carried out between January 1, 2005, and Dec 31, 2010.
The patients were divided into the following three clinical groups for comparison.
Group A; Patients with typical clinical characteristics of anti–NMDAR encephalitis.
Group B; Patients with narcolepsy with severe psychosis.
Group C; Patients with schizophrenia or schizo–affective disorders.
Ten out of 61 cases were anti–NMDAR antibody positive in typical encephalitis cases (group A: 3 of 5 cases) and cases in a broader range of psychiatric disorders including narcolepsy (group B: 3 of 5 cases) and schizophrenia (group C: 4 of 51 cases).
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