Previously unknown thyroid dysfunction in patients with acute ischemic stroke

Acta Neurologica Scandinavica, 05/07/2012

In patients with first–time acute ischemic stroke, unknown thyroid dysfunction is common, and unknown overt or subclinical hyperthyroidism is associated with cardio–embolic stroke.


  • A total of 153 Swedish patients diagnosed with first-time acute ischemic stroke were included in the study and categorized for suspected cardio-embolic (n = 30) or non-embolic (n = 123) ischemic stroke depending on the presence of atrial fibrillation (AF).
  • Blood samples were taken 48 h or earlier after onset of stroke symptoms.


  • Previously, unknown overt or subclinical thyroid dysfunction was found in 12%.
  • Previously, unknown overt or subclinical hyperthyroidism was more common in the AF group (13%) compared to the non-AF group (3%), P = 0.048.
  • Patients with AF had slightly higher concentrations of free T4 (15 vs 14 pm; P < 0.001), but there was no significant difference in concentrations of S-TSH or prevalence of thyroperoxidase (TPO) antibodies between the groups.

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