Amyloid Plaques Dissociate Pentameric to Monomeric C-Reactive Protein: A Novel Pathomechanism Driving Cortical Inflammation in Alzheimers Disease

Brain Pathology, 05/07/2012

The existence of pCRP to individual monomers (mCRP) but not pentameric C–reactive protein (pCRP) in the brains of Alzheimer's disease patients strongly indicates that this newly described biological effect of Beta–amyloid (Aβ) plaques is relevant in Alzheimer pathobiology; potentially localizing and amplifying inflammation via the strong pro–inflammatory effects of locally generated mCRP.

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